Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab.
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| Title: | Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab. |
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| Authors: | Lin S; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Kennedy NA; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Saifuddin A; Department of Gastroenterology, St Marks Hospital and Academic Institute, London, UK.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Sandoval DM; Department of Infectious Disease, Imperial College London, London, UK., Reynolds CJ; Department of Infectious Disease, Imperial College London, London, UK., Seoane RC; Department of Immunology and Inflammation, Imperial College London, London, United Kingdom., Kottoor SH; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Pieper FP; Department of Infectious Disease, Imperial College London, London, UK., Lin KM; Department of Infectious Disease, Imperial College London, London, UK., Butler DK; Department of Infectious Disease, Imperial College London, London, UK., Chanchlani N; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Nice R; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.; Department of Biochemistry, Exeter Clinical Laboratory International, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Chee D; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Bewshea C; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Janjua M; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., McDonald TJ; Department of Biochemistry, Exeter Clinical Laboratory International, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Sebastian S; IBD Unit, Department of Gastroenterology, Hull University Teaching Hospitals NHS Trust, Hull, UK.; Hull York Medical School, University of Hull, Hull, UK., Alexander JL; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK., Constable L; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Lee JC; Department of Gastroenterology, Royal Free London NHS Foundation Trust, London, UK.; Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Murray CD; Department of Gastroenterology, Royal Free London NHS Foundation Trust, London, UK., Hart AL; Department of Gastroenterology, St Marks Hospital and Academic Institute, London, UK., Irving PM; Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, UK.; School of Immunology & Microbial Sciences, King's College London, London, UK., Jones GR; Department of Gastroenterology, Western General Hospital, NHS Lothian, Edinburgh, UK.; Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK., Kok KB; Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust, London, UK.; Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK., Lamb CA; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Lees CW; Department of Gastroenterology, Western General Hospital, NHS Lothian, Edinburgh, UK.; Institute of Genetic and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Altmann DM; Department of Immunology and Inflammation, Imperial College London, London, United Kingdom., Boyton RJ; Department of Infectious Disease, Imperial College London, London, UK.; Lung Division, Royal Brompton Hospital and Harefield Hospitals, London, UK., Goodhand JR; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Powell N; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK., Ahmad T; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK. tariq.ahmad1@nhs.net.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK. tariq.ahmad1@nhs.net. |
| Corporate Authors: | CLARITY IBD study |
| Source: | Nature communications [Nat Commun] 2022 Mar 16; Vol. 13 (1), pp. 1379. Date of Electronic Publication: 2022 Mar 16. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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