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A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors.

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Title: A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors.
Authors: Liang R; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States., Tomita D; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States., Sasaki Y; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States., Ginn J; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States., Michino M; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States., Huggins DJ; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York 10021, United States., Baxt L; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States., Kargman S; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States., Shahid M; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Epigenetics Program, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States.; Abramson Cancer Center, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States., Aso K; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States., Duggan M; LifeSci Consulting, LLC., 18243 SE Ridgeview Drive, Tequesta, Florida 33469, United States., Stamford AW; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States., DeStanchina E; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States., Liverton N; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States., Meinke PT; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.; Department of Pharmacology, Weill Cornell Medical College, New York, New York 10021, United States., Foley MA; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States., Phillips RE; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Epigenetics Program, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States.; Abramson Cancer Center, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Feb 10; Vol. 13 (3), pp. 377-387. Date of Electronic Publication: 2022 Feb 10 (Print Publication: 2022).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Liang+R%22">Liang R</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Tomita+D%22">Tomita D</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Sasaki+Y%22">Sasaki Y</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Ginn+J%22">Ginn J</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Michino+M%22">Michino M</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Huggins+DJ%22">Huggins DJ</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Baxt+L%22">Baxt L</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Kargman+S%22">Kargman S</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Shahid+M%22">Shahid M</searchLink>; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Epigenetics Program, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States.; Abramson Cancer Center, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States.<br /><searchLink fieldCode="AU" term="%22Aso+K%22">Aso K</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Duggan+M%22">Duggan M</searchLink>; LifeSci Consulting, LLC., 18243 SE Ridgeview Drive, Tequesta, Florida 33469, United States.<br /><searchLink fieldCode="AU" term="%22Stamford+AW%22">Stamford AW</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22DeStanchina+E%22">DeStanchina E</searchLink>; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.<br /><searchLink fieldCode="AU" term="%22Liverton+N%22">Liverton N</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Meinke+PT%22">Meinke PT</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.; Department of Pharmacology, Weill Cornell Medical College, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Foley+MA%22">Foley MA</searchLink>; Tri-Institutional Therapeutics Discovery Institute, 413 East 69th Street, New York, New York 10021, United States.<br /><searchLink fieldCode="AU" term="%22Phillips+RE%22">Phillips RE</searchLink>; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Epigenetics Program, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States.; Abramson Cancer Center, Perelman School of Medicine, Philadelphia, Pennsylvania 19104, United States.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2022 Feb 10; Vol. 13 (3), pp. 377-387. <i>Date of Electronic Publication: </i>2022 Feb 10 (<i>Print Publication: </i>2022).
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