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Regulation of PGC1α Downstream of the Insulin Signaling Pathway Plays a Role in the Hepatic Proteotoxicity of Mutant α1-Antitrypsin Deficiency Variant Z.

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Title: Regulation of PGC1α Downstream of the Insulin Signaling Pathway Plays a Role in the Hepatic Proteotoxicity of Mutant α1-Antitrypsin Deficiency Variant Z.
Authors: Rudnick DA; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri; Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri. Electronic address: rudnick_d@wustl.edu., Huang J; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri., Hidvegi T; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri., Chu AS; Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Hale P; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri., Munanairi A; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri., Dietzen DJ; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri., Cliften PF; Department of Genetics, Washington University School of Medicine, St Louis, Missouri; The Genome Technology Access Center, Washington University School of Medicine, St Louis, Missouri., Tycksen E; The Genome Technology Access Center, Washington University School of Medicine, St Louis, Missouri., Lutkewitte AJ; Department of Medicine, Washington University School of Medicine, St Louis, Missouri., Finck BN; Department of Medicine, Washington University School of Medicine, St Louis, Missouri., Pak SC; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri., Silverman GA; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri., Perlmutter DH; Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri; Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri.
Source: Gastroenterology [Gastroenterology] 2022 Jul; Vol. 163 (1), pp. 270-284. Date of Electronic Publication: 2022 Mar 15.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1528-0012
DOI:10.1053/j.gastro.2022.03.010