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Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.

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Title: Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.
Authors: Avet C; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Mancini A; Domain Therapeutics North America, Montréal, Canada., Breton B; Domain Therapeutics North America, Montréal, Canada., Le Gouill C; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Hauser AS; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Normand C; Domain Therapeutics North America, Montréal, Canada., Kobayashi H; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Gross F; Domain Therapeutics North America, Montréal, Canada., Hogue M; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Lukasheva V; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., St-Onge S; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Carrier M; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Héroux M; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada., Morissette S; Domain Therapeutics North America, Montréal, Canada., Fauman EB; Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, United States., Fortin JP; Pfizer Global R&D, Cambridge, United States., Schann S; Domain Therapeutics, Illkirch-Strasbourg, France., Leroy X; Domain Therapeutics, Illkirch-Strasbourg, France., Gloriam DE; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Bouvier M; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada.
Source: ELife [Elife] 2022 Mar 18; Vol. 11. Date of Electronic Publication: 2022 Mar 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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  Data: Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.
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  Data: <searchLink fieldCode="AU" term="%22Avet+C%22">Avet C</searchLink>; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Mancini+A%22">Mancini A</searchLink>; Domain Therapeutics North America, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Breton+B%22">Breton B</searchLink>; Domain Therapeutics North America, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Le+Gouill+C%22">Le Gouill C</searchLink>; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Hauser+AS%22">Hauser AS</searchLink>; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Normand+C%22">Normand C</searchLink>; Domain Therapeutics North America, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Kobayashi+H%22">Kobayashi H</searchLink>; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Gross+F%22">Gross F</searchLink>; Domain Therapeutics North America, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Hogue+M%22">Hogue M</searchLink>; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Lukasheva+V%22">Lukasheva V</searchLink>; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22St-Onge+S%22">St-Onge S</searchLink>; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Carrier+M%22">Carrier M</searchLink>; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Héroux+M%22">Héroux M</searchLink>; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Morissette+S%22">Morissette S</searchLink>; Domain Therapeutics North America, Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Fauman+EB%22">Fauman EB</searchLink>; Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, United States.<br /><searchLink fieldCode="AU" term="%22Fortin+JP%22">Fortin JP</searchLink>; Pfizer Global R&D, Cambridge, United States.<br /><searchLink fieldCode="AU" term="%22Schann+S%22">Schann S</searchLink>; Domain Therapeutics, Illkirch-Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Leroy+X%22">Leroy X</searchLink>; Domain Therapeutics, Illkirch-Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Gloriam+DE%22">Gloriam DE</searchLink>; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Bouvier+M%22">Bouvier M</searchLink>; Institute for Research in Immunology and Cancer (IRIC), and Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, Canada.
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  Data: <searchLink fieldCode="JN" term="%22101579614%22">ELife</searchLink> [Elife] 2022 Mar 18; Vol. 11. <i>Date of Electronic Publication: </i>2022 Mar 18.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22eLife+Sciences+Publications%2C+Ltd%22">eLife Sciences Publications, Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101579614 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2050-084X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222050084X%22">2050084X </searchLink><i>NLM ISO Abbreviation: </i>Elife <i>Subsets: </i>MEDLINE
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