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Tumor-reactive antibodies evolve from non-binding and autoreactive precursors.

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Title: Tumor-reactive antibodies evolve from non-binding and autoreactive precursors.
Authors: Mazor RD; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel., Nathan N; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel., Gilboa A; Faculty of Engineering, Bar Ilan University, Ramat Gan 52900, Israel., Stoler-Barak L; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel., Moss L; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel., Solomonov I; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel., Hanuna A; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel., Divinsky Y; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel., Shmueli MD; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel., Hezroni H; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel., Zaretsky I; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel; Department of Life Sciences and Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel., Mor M; Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel., Golani O; Department of Life Sciences and Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel., Sabah G; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel., Jakobson-Setton A; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel., Yanichkin N; Department of Pathology, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel., Feinmesser M; Department of Pathology, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel., Tsoref D; Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel., Salman L; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel., Yeoshoua E; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel., Peretz E; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel., Erlich I; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel., Cohen NM; Department of Mathematics and Computer Science, Weizmann Institute of Science, Rehovot 7610001, Israel., Gershoni JM; Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv-Yafo, Israel., Freund N; Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel., Merbl Y; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel., Yaari G; Faculty of Engineering, Bar Ilan University, Ramat Gan 52900, Israel., Eitan R; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel., Sagi I; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: irit.sagi@weizmann.ac.il., Shulman Z; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: ziv.shulman@weizmann.ac.il.
Source: Cell [Cell] 2022 Mar 31; Vol. 185 (7), pp. 1208-1222.e21. Date of Electronic Publication: 2022 Mar 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: Tumor-reactive antibodies evolve from non-binding and autoreactive precursors.
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  Data: <searchLink fieldCode="AU" term="%22Mazor+RD%22">Mazor RD</searchLink>; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Nathan+N%22">Nathan N</searchLink>; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Gilboa+A%22">Gilboa A</searchLink>; Faculty of Engineering, Bar Ilan University, Ramat Gan 52900, Israel.<br /><searchLink fieldCode="AU" term="%22Stoler-Barak+L%22">Stoler-Barak L</searchLink>; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Moss+L%22">Moss L</searchLink>; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Solomonov+I%22">Solomonov I</searchLink>; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Hanuna+A%22">Hanuna A</searchLink>; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Divinsky+Y%22">Divinsky Y</searchLink>; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Shmueli+MD%22">Shmueli MD</searchLink>; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Hezroni+H%22">Hezroni H</searchLink>; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Zaretsky+I%22">Zaretsky I</searchLink>; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel; Department of Life Sciences and Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Mor+M%22">Mor M</searchLink>; Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Golani+O%22">Golani O</searchLink>; Department of Life Sciences and Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Sabah+G%22">Sabah G</searchLink>; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Jakobson-Setton+A%22">Jakobson-Setton A</searchLink>; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Yanichkin+N%22">Yanichkin N</searchLink>; Department of Pathology, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Feinmesser+M%22">Feinmesser M</searchLink>; Department of Pathology, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Tsoref+D%22">Tsoref D</searchLink>; Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Salman+L%22">Salman L</searchLink>; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Yeoshoua+E%22">Yeoshoua E</searchLink>; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Peretz+E%22">Peretz E</searchLink>; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel.<br /><searchLink fieldCode="AU" term="%22Erlich+I%22">Erlich I</searchLink>; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel.<br /><searchLink fieldCode="AU" term="%22Cohen+NM%22">Cohen NM</searchLink>; Department of Mathematics and Computer Science, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Gershoni+JM%22">Gershoni JM</searchLink>; Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Freund+N%22">Freund N</searchLink>; Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Merbl+Y%22">Merbl Y</searchLink>; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Yaari+G%22">Yaari G</searchLink>; Faculty of Engineering, Bar Ilan University, Ramat Gan 52900, Israel.<br /><searchLink fieldCode="AU" term="%22Eitan+R%22">Eitan R</searchLink>; Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Sagi+I%22">Sagi I</searchLink>; Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: irit.sagi@weizmann.ac.il.<br /><searchLink fieldCode="AU" term="%22Shulman+Z%22">Shulman Z</searchLink>; Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: ziv.shulman@weizmann.ac.il.
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  Data: <searchLink fieldCode="JN" term="%220413066%22">Cell</searchLink> [Cell] 2022 Mar 31; Vol. 185 (7), pp. 1208-1222.e21. <i>Date of Electronic Publication: </i>2022 Mar 18.
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