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Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML.

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Title: Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML.
Authors: Salmon JM; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Australian Centre for Blood Diseases, Monash University and The Alfred Hospital, Melbourne, Australia., Todorovski I; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Stanley KL; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Bruedigam C; Cancer Program, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Medicine, University of Queensland, Brisbane, Queensland, Australia., Kearney CJ; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Martelotto LG; Single Cell Innovation Lab, Department of Clinical Pathology, University of Melbourne, Parkville, Victoria, Australia., Rossello F; Single Cell Innovation Lab, Department of Clinical Pathology, University of Melbourne, Parkville, Victoria, Australia.; University of Melbourne Centre for Cancer Research, The University of Melbourne, Melbourne, Victoria, Australia., Semple T; Molecular Genomics Core, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Arnau GM; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Molecular Genomics Core, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Zethoven M; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Bots M; Laboratory of Clinical Chemistry, Academic Medical Center, University of Amsterdam, the Netherlands., Bjelosevic S; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Cluse LA; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Fraser PJ; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Litalien V; Australian Centre for Blood Diseases, Monash University and The Alfred Hospital, Melbourne, Australia., Vidacs E; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., McArthur K; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia., Matthews AY; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Sciences, Monash University Clayton Victoria, Australia., Gressier E; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia., de Weerd NA; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Sciences, Monash University Clayton Victoria, Australia., Lichte J; Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, Düsseldorf, Germany., Kelly MJ; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Hogg SJ; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Hertzog PJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Sciences, Monash University Clayton Victoria, Australia., Kats LM; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Vervoort SJ; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., De Carvalho DD; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada., Scheu S; Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, Düsseldorf, Germany., Bedoui S; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia., Kile BT; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia., Lane SW; Cancer Program, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Medicine, University of Queensland, Brisbane, Queensland, Australia., Perkins AC; Australian Centre for Blood Diseases, Monash University and The Alfred Hospital, Melbourne, Australia., Wei AH; Australian Centre for Blood Diseases, Monash University and The Alfred Hospital, Melbourne, Australia., Dominguez PM; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Johnstone RW; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
Source: Cancer discovery [Cancer Discov] 2022 Jun 02; Vol. 12 (6), pp. 1560-1579.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML.
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  Data: <searchLink fieldCode="AU" term="%22Salmon+JM%22">Salmon JM</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Australian Centre for Blood Diseases, Monash University and The Alfred Hospital, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Todorovski+I%22">Todorovski I</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Stanley+KL%22">Stanley KL</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Bruedigam+C%22">Bruedigam C</searchLink>; Cancer Program, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Medicine, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Kearney+CJ%22">Kearney CJ</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Martelotto+LG%22">Martelotto LG</searchLink>; Single Cell Innovation Lab, Department of Clinical Pathology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Rossello+F%22">Rossello F</searchLink>; Single Cell Innovation Lab, Department of Clinical Pathology, University of Melbourne, Parkville, Victoria, Australia.; University of Melbourne Centre for Cancer Research, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Semple+T%22">Semple T</searchLink>; Molecular Genomics Core, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Arnau+GM%22">Arnau GM</searchLink>; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Molecular Genomics Core, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Zethoven+M%22">Zethoven M</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Bots+M%22">Bots M</searchLink>; Laboratory of Clinical Chemistry, Academic Medical Center, University of Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bjelosevic+S%22">Bjelosevic S</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Cluse+LA%22">Cluse LA</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Fraser+PJ%22">Fraser PJ</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Litalien+V%22">Litalien V</searchLink>; Australian Centre for Blood Diseases, Monash University and The Alfred Hospital, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Vidacs+E%22">Vidacs E</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22McArthur+K%22">McArthur K</searchLink>; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Matthews+AY%22">Matthews AY</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Sciences, Monash University Clayton Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Gressier+E%22">Gressier E</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22de+Weerd+NA%22">de Weerd NA</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Sciences, Monash University Clayton Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Lichte+J%22">Lichte J</searchLink>; Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Kelly+MJ%22">Kelly MJ</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Hogg+SJ%22">Hogg SJ</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Hertzog+PJ%22">Hertzog PJ</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Sciences, Monash University Clayton Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kats+LM%22">Kats LM</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Vervoort+SJ%22">Vervoort SJ</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22De+Carvalho+DD%22">De Carvalho DD</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Scheu+S%22">Scheu S</searchLink>; Institute of Medical Microbiology and Hospital Hygiene, University of Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Bedoui+S%22">Bedoui S</searchLink>; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kile+BT%22">Kile BT</searchLink>; Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Lane+SW%22">Lane SW</searchLink>; Cancer Program, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Medicine, University of Queensland, Brisbane, Queensland, Australia.<br /><searchLink fieldCode="AU" term="%22Perkins+AC%22">Perkins AC</searchLink>; Australian Centre for Blood Diseases, Monash University and The Alfred Hospital, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Wei+AH%22">Wei AH</searchLink>; Australian Centre for Blood Diseases, Monash University and The Alfred Hospital, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Dominguez+PM%22">Dominguez PM</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Johnstone+RW%22">Johnstone RW</searchLink>; Translational Haematology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
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