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Safety and long-term improvement of mesenchymal stromal cell infusion in critically COVID-19 patients: a randomized clinical trial.

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Title: Safety and long-term improvement of mesenchymal stromal cell infusion in critically COVID-19 patients: a randomized clinical trial.
Authors: Rebelatto CLK; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil. carmen.rebelatto@pucpr.br.; Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil. carmen.rebelatto@pucpr.br.; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil. carmen.rebelatto@pucpr.br., Senegaglia AC; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil.; Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil., Franck CL; Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil., Daga DR; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil.; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil., Shigunov P; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil.; Laboratory of Basic Biology of Stem Cells, Carlos Chagas Institute, Fiocruz-Paraná, Curitiba, PR, Brazil., Stimamiglio MA; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil.; Laboratory of Basic Biology of Stem Cells, Carlos Chagas Institute, Fiocruz-Paraná, Curitiba, PR, Brazil., Marsaro DB; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil.; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil., Schaidt B; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil., Micosky A; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil., de Azambuja AP; Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil., Leitão CA; Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil., Petterle RR; Statistics, Health Sciences Sector, Federal University of Paraná, Curitiba, PR, Brazil., Jamur VR; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil., Vaz IM; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil., Mallmann AP; Hospital e Maternidade Brígida, Curitiba, PR, Brazil., Carraro Junior H; Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil., Ditzel E; Hospital Nossa Senhora do Pilar, Curitiba, PR, Brazil., Brofman PRS; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil.; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil., Correa A; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil.; Laboratory of Basic Biology of Stem Cells, Carlos Chagas Institute, Fiocruz-Paraná, Curitiba, PR, Brazil.
Source: Stem cell research & therapy [Stem Cell Res Ther] 2022 Mar 21; Vol. 13 (1), pp. 122. Date of Electronic Publication: 2022 Mar 21.
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety and long-term improvement of mesenchymal stromal cell infusion in critically COVID-19 patients: a randomized clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Rebelatto+CLK%22">Rebelatto CLK</searchLink>; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil. carmen.rebelatto@pucpr.br.; Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil. carmen.rebelatto@pucpr.br.; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil. carmen.rebelatto@pucpr.br.<br /><searchLink fieldCode="AU" term="%22Senegaglia+AC%22">Senegaglia AC</searchLink>; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil.; Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Franck+CL%22">Franck CL</searchLink>; Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Daga+DR%22">Daga DR</searchLink>; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil.; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Shigunov+P%22">Shigunov P</searchLink>; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil.; Laboratory of Basic Biology of Stem Cells, Carlos Chagas Institute, Fiocruz-Paraná, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Stimamiglio+MA%22">Stimamiglio MA</searchLink>; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil.; Laboratory of Basic Biology of Stem Cells, Carlos Chagas Institute, Fiocruz-Paraná, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Marsaro+DB%22">Marsaro DB</searchLink>; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil.; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Schaidt+B%22">Schaidt B</searchLink>; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Micosky+A%22">Micosky A</searchLink>; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Azambuja+AP%22">de Azambuja AP</searchLink>; Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Leitão+CA%22">Leitão CA</searchLink>; Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Petterle+RR%22">Petterle RR</searchLink>; Statistics, Health Sciences Sector, Federal University of Paraná, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Jamur+VR%22">Jamur VR</searchLink>; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Vaz+IM%22">Vaz IM</searchLink>; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil.<br /><searchLink fieldCode="AU" term="%22Mallmann+AP%22">Mallmann AP</searchLink>; Hospital e Maternidade Brígida, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Carraro+Junior+H%22">Carraro Junior H</searchLink>; Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Ditzel+E%22">Ditzel E</searchLink>; Hospital Nossa Senhora do Pilar, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Brofman+PRS%22">Brofman PRS</searchLink>; Core for Cell Technology, School of Medicine, Pontifícia Universidade Católica Do Paraná, 1155 Imaculada Conceição Street, Prado Velho, Curitiba, PR, 80215-901, Brazil.; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Correa+A%22">Correa A</searchLink>; National Institute of Science and Technology for Regenerative Medicine, INCT-REGENERA, Rio de Janeiro, Brazil.; Laboratory of Basic Biology of Stem Cells, Carlos Chagas Institute, Fiocruz-Paraná, Curitiba, PR, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101527581%22">Stem cell research & therapy</searchLink> [Stem Cell Res Ther] 2022 Mar 21; Vol. 13 (1), pp. 122. <i>Date of Electronic Publication: </i>2022 Mar 21.
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