A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
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| Title: | A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. |
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| Authors: | Sebastian C; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy. csebastian@ub.edu.; Departament de Biologia Cel.lular, Fisiologia i Immunologia, Facultad de Biologia, Universitat de Barcelona (UB), 08028, Barcelona, Spain. csebastian@ub.edu.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), 08028, Barcelona, Spain. csebastian@ub.edu., Ferrer C; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA, 02114, USA., Serra M; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy., Choi JE; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA, 02114, USA., Ducano N; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy., Mira A; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy., Shah MS; Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA., Stopka SA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Perciaccante AJ; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; University of Georgia, Athens, GA, USA., Isella C; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Oncology, University of Torino, Turin, Italy., Moya-Rull D; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Oncology, University of Torino, Turin, Italy., Vara-Messler M; Department of Oncology, University of Torino, Turin, Italy.; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Experimentale et Clinique (IREC), UCLeuven, Brussels, Belgium., Giordano S; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Oncology, University of Torino, Turin, Italy., Maldi E; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy., Desai N; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Capen DE; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Medico E; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Oncology, University of Torino, Turin, Italy., Cetinbas M; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Sadreyev RI; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Brown D; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Rivera MN; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Sapino A; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Medical Sciences, University of Torino, Turin, Italy., Breault DT; Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 02138, USA., Agar NYR; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA., Mostoslavsky R; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA. rmostoslavsky@mgh.harvard.edu.; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA, 02114, USA. rmostoslavsky@mgh.harvard.edu.; The Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. rmostoslavsky@mgh.harvard.edu. |
| Source: | Nature communications [Nat Commun] 2022 Mar 21; Vol. 13 (1), pp. 1503. Date of Electronic Publication: 2022 Mar 21. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-29085-y |
