View in EDS HTML Full Text PDF Full Text

A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.

Saved in:
Bibliographic Details
Title: A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
Authors: Sebastian C; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy. csebastian@ub.edu.; Departament de Biologia Cel.lular, Fisiologia i Immunologia, Facultad de Biologia, Universitat de Barcelona (UB), 08028, Barcelona, Spain. csebastian@ub.edu.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), 08028, Barcelona, Spain. csebastian@ub.edu., Ferrer C; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA, 02114, USA., Serra M; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy., Choi JE; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA, 02114, USA., Ducano N; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy., Mira A; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy., Shah MS; Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA., Stopka SA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Perciaccante AJ; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; University of Georgia, Athens, GA, USA., Isella C; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Oncology, University of Torino, Turin, Italy., Moya-Rull D; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Oncology, University of Torino, Turin, Italy., Vara-Messler M; Department of Oncology, University of Torino, Turin, Italy.; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Experimentale et Clinique (IREC), UCLeuven, Brussels, Belgium., Giordano S; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Oncology, University of Torino, Turin, Italy., Maldi E; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy., Desai N; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Capen DE; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Medico E; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Oncology, University of Torino, Turin, Italy., Cetinbas M; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Sadreyev RI; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Brown D; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Rivera MN; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA., Sapino A; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Medical Sciences, University of Torino, Turin, Italy., Breault DT; Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 02138, USA., Agar NYR; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA., Mostoslavsky R; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA. rmostoslavsky@mgh.harvard.edu.; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA, 02114, USA. rmostoslavsky@mgh.harvard.edu.; The Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. rmostoslavsky@mgh.harvard.edu.
Source: Nature communications [Nat Commun] 2022 Mar 21; Vol. 13 (1), pp. 1503. Date of Electronic Publication: 2022 Mar 21.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 35314684
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Sebastian+C%22">Sebastian C</searchLink>; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy. csebastian@ub.edu.; Departament de Biologia Cel.lular, Fisiologia i Immunologia, Facultad de Biologia, Universitat de Barcelona (UB), 08028, Barcelona, Spain. csebastian@ub.edu.; Institut de Biomedicina de la Universitat de Barcelona (IBUB), 08028, Barcelona, Spain. csebastian@ub.edu.<br /><searchLink fieldCode="AU" term="%22Ferrer+C%22">Ferrer C</searchLink>; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Serra+M%22">Serra M</searchLink>; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.<br /><searchLink fieldCode="AU" term="%22Choi+JE%22">Choi JE</searchLink>; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Ducano+N%22">Ducano N</searchLink>; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.<br /><searchLink fieldCode="AU" term="%22Mira+A%22">Mira A</searchLink>; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.<br /><searchLink fieldCode="AU" term="%22Shah+MS%22">Shah MS</searchLink>; Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Stopka+SA%22">Stopka SA</searchLink>; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Perciaccante+AJ%22">Perciaccante AJ</searchLink>; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; University of Georgia, Athens, GA, USA.<br /><searchLink fieldCode="AU" term="%22Isella+C%22">Isella C</searchLink>; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Oncology, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Moya-Rull+D%22">Moya-Rull D</searchLink>; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Oncology, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Vara-Messler+M%22">Vara-Messler M</searchLink>; Department of Oncology, University of Torino, Turin, Italy.; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Experimentale et Clinique (IREC), UCLeuven, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Giordano+S%22">Giordano S</searchLink>; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Oncology, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Maldi+E%22">Maldi E</searchLink>; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.<br /><searchLink fieldCode="AU" term="%22Desai+N%22">Desai N</searchLink>; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Capen+DE%22">Capen DE</searchLink>; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Medico+E%22">Medico E</searchLink>; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Oncology, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Cetinbas+M%22">Cetinbas M</searchLink>; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Sadreyev+RI%22">Sadreyev RI</searchLink>; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Brown+D%22">Brown D</searchLink>; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Rivera+MN%22">Rivera MN</searchLink>; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA.; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Sapino+A%22">Sapino A</searchLink>; Candiolo Cancer Institute-FPO, IRCCS, Candiolo, 10060, Italy.; Department of Medical Sciences, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Breault+DT%22">Breault DT</searchLink>; Division of Endocrinology, Boston Children's Hospital, Boston, MA, 02115, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 02138, USA.<br /><searchLink fieldCode="AU" term="%22Agar+NYR%22">Agar NYR</searchLink>; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Mostoslavsky+R%22">Mostoslavsky R</searchLink>; The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA. rmostoslavsky@mgh.harvard.edu.; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA, 02114, USA. rmostoslavsky@mgh.harvard.edu.; The Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. rmostoslavsky@mgh.harvard.edu.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2022 Mar 21; Vol. 13 (1), pp. 1503. <i>Date of Electronic Publication: </i>2022 Mar 21.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=35314684
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-022-29085-y
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1503
    Titles:
      – TitleFull: A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sebastian C
      – PersonEntity:
          Name:
            NameFull: Ferrer C
      – PersonEntity:
          Name:
            NameFull: Serra M
      – PersonEntity:
          Name:
            NameFull: Choi JE
      – PersonEntity:
          Name:
            NameFull: Ducano N
      – PersonEntity:
          Name:
            NameFull: Mira A
      – PersonEntity:
          Name:
            NameFull: Shah MS
      – PersonEntity:
          Name:
            NameFull: Stopka SA
      – PersonEntity:
          Name:
            NameFull: Perciaccante AJ
      – PersonEntity:
          Name:
            NameFull: Isella C
      – PersonEntity:
          Name:
            NameFull: Moya-Rull D
      – PersonEntity:
          Name:
            NameFull: Vara-Messler M
      – PersonEntity:
          Name:
            NameFull: Giordano S
      – PersonEntity:
          Name:
            NameFull: Maldi E
      – PersonEntity:
          Name:
            NameFull: Desai N
      – PersonEntity:
          Name:
            NameFull: Capen DE
      – PersonEntity:
          Name:
            NameFull: Medico E
      – PersonEntity:
          Name:
            NameFull: Cetinbas M
      – PersonEntity:
          Name:
            NameFull: Sadreyev RI
      – PersonEntity:
          Name:
            NameFull: Brown D
      – PersonEntity:
          Name:
            NameFull: Rivera MN
      – PersonEntity:
          Name:
            NameFull: Sapino A
      – PersonEntity:
          Name:
            NameFull: Breault DT
      – PersonEntity:
          Name:
            NameFull: Agar NYR
      – PersonEntity:
          Name:
            NameFull: Mostoslavsky R
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 21
              M: 03
              Text: 2022 Mar 21
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 13
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1