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Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells.

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Title: Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells.
Authors: Ali M; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA., Lu M; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA., Ang HX; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA., Soderquist RS; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA., Eyler CE; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA., Hutchinson HM; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA., Glass C; Department of Pathology, Duke University, Durham, NC 27710, USA., Bassil CF; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA., Lopez OM; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA., Kerr DL; Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA., Falcon CJ; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA., Yu HA; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA., Hata AN; Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA., Blakely CM; Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA., McCoach CE; Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA., Bivona TG; Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA., Wood KC; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA.
Source: Science translational medicine [Sci Transl Med] 2022 Mar 30; Vol. 14 (638), pp. eabc7480. Date of Electronic Publication: 2022 Mar 30.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells.
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  Data: <searchLink fieldCode="AU" term="%22Ali+M%22">Ali M</searchLink>; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Lu+M%22">Lu M</searchLink>; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Ang+HX%22">Ang HX</searchLink>; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Soderquist+RS%22">Soderquist RS</searchLink>; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Eyler+CE%22">Eyler CE</searchLink>; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Hutchinson+HM%22">Hutchinson HM</searchLink>; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Glass+C%22">Glass C</searchLink>; Department of Pathology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Bassil+CF%22">Bassil CF</searchLink>; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Lopez+OM%22">Lopez OM</searchLink>; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Kerr+DL%22">Kerr DL</searchLink>; Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Falcon+CJ%22">Falcon CJ</searchLink>; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Yu+HA%22">Yu HA</searchLink>; Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Hata+AN%22">Hata AN</searchLink>; Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.<br /><searchLink fieldCode="AU" term="%22Blakely+CM%22">Blakely CM</searchLink>; Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22McCoach+CE%22">McCoach CE</searchLink>; Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Bivona+TG%22">Bivona TG</searchLink>; Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.<br /><searchLink fieldCode="AU" term="%22Wood+KC%22">Wood KC</searchLink>; Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC 27710, USA.
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