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The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.

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Title: The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.
Authors: Jacobsen AV; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Pierotti CL; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Lowes KN; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Au AE; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Zhang Y; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Etemadi N; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Fitzgibbon C; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Kersten WJA; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia., Samson AL; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., van Delft MF; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Huang DCS; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Sabroux HJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia., Lessene G; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.; Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, VIC, Australia., Silke J; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. silke@wehi.edu.au.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. silke@wehi.edu.au., Murphy JM; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. jamesm@wehi.edu.au.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. jamesm@wehi.edu.au.
Source: Cell death & disease [Cell Death Dis] 2022 Apr 01; Vol. 13 (4), pp. 291. Date of Electronic Publication: 2022 Apr 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.
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  Data: <searchLink fieldCode="AU" term="%22Jacobsen+AV%22">Jacobsen AV</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Pierotti+CL%22">Pierotti CL</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lowes+KN%22">Lowes KN</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Au+AE%22">Au AE</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Etemadi+N%22">Etemadi N</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Fitzgibbon+C%22">Fitzgibbon C</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kersten+WJA%22">Kersten WJA</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Samson+AL%22">Samson AL</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22van+Delft+MF%22">van Delft MF</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Huang+DCS%22">Huang DCS</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Sabroux+HJ%22">Sabroux HJ</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Lessene+G%22">Lessene G</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia.; Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Silke+J%22">Silke J</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. silke@wehi.edu.au.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. silke@wehi.edu.au.<br /><searchLink fieldCode="AU" term="%22Murphy+JM%22">Murphy JM</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. jamesm@wehi.edu.au.; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. jamesm@wehi.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2022 Apr 01; Vol. 13 (4), pp. 291. <i>Date of Electronic Publication: </i>2022 Apr 01.
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        Value: 10.1038/s41419-022-04740-w
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      – TitleFull: The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.
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