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LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma.

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Title: LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma.
Authors: Gur C; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Wang SY; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel. Electronic address: shuangyinwang@me.com., Sheban F; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Zada M; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Li B; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Kharouf F; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Peleg H; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Aamar S; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Yalin A; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Kirschenbaum D; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Braun-Moscovici Y; Rheumatology Institute, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion-Israeli Institute of Technology, Haifa, Israel., Jaitin DA; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Meir-Salame T; Flow Cytometry Unit, Department of Biological Services, Weizmann Institute, Rehovot, Israel., Hagai E; Flow Cytometry Unit, Department of Biological Services, Weizmann Institute, Rehovot, Israel., Kragesteen BK; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Avni B; Department of Bone Marrow Transplantation, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Grisariu S; Department of Bone Marrow Transplantation, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Bornstein C; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Shlomi-Loubaton S; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., David E; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Shreberk-Hassidim R; Dermatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Molho-Pessach V; Dermatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Amar D; Plastic Surgery Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Tzur T; Plastic Surgery Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Kuint R; Institue of Pulmonology Medicine, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Gross M; Orthopedic Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Barboy O; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Moshe A; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Fellus-Alyagor L; The Department of Veterinary Resources, Weizmann Institute, Rehovot, Israel., Hirsch D; The Department of Veterinary Resources, Weizmann Institute, Rehovot, Israel., Addadi Y; Life Sciences Core Facilities, Weizmann Institute, Rehovot, Israel., Erenfeld S; Department of Bone Marrow Transplantation, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Biton M; Department of Biological Regulation, Weizmann Institute, Rehovot, Israel., Tzemach T; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Elazary A; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Naparstek Y; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel., Tzemach R; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel; Rheumatology Institute at the Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel., Weiner A; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Giladi A; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel., Balbir-Gurman A; Rheumatology Institute, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion-Israeli Institute of Technology, Haifa, Israel., Amit I; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel. Electronic address: ido.amit@weizmann.ac.il.
Source: Cell [Cell] 2022 Apr 14; Vol. 185 (8), pp. 1373-1388.e20. Date of Electronic Publication: 2022 Apr 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
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  Data: LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma.
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  Data: <searchLink fieldCode="AU" term="%22Gur+C%22">Gur C</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Wang+SY%22">Wang SY</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel. Electronic address: shuangyinwang@me.com.<br /><searchLink fieldCode="AU" term="%22Sheban+F%22">Sheban F</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Zada+M%22">Zada M</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Kharouf+F%22">Kharouf F</searchLink>; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Peleg+H%22">Peleg H</searchLink>; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Aamar+S%22">Aamar S</searchLink>; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Yalin+A%22">Yalin A</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Kirschenbaum+D%22">Kirschenbaum D</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Braun-Moscovici+Y%22">Braun-Moscovici Y</searchLink>; Rheumatology Institute, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion-Israeli Institute of Technology, Haifa, Israel.<br /><searchLink fieldCode="AU" term="%22Jaitin+DA%22">Jaitin DA</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Meir-Salame+T%22">Meir-Salame T</searchLink>; Flow Cytometry Unit, Department of Biological Services, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Hagai+E%22">Hagai E</searchLink>; Flow Cytometry Unit, Department of Biological Services, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Kragesteen+BK%22">Kragesteen BK</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Avni+B%22">Avni B</searchLink>; Department of Bone Marrow Transplantation, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Grisariu+S%22">Grisariu S</searchLink>; Department of Bone Marrow Transplantation, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Bornstein+C%22">Bornstein C</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Shlomi-Loubaton+S%22">Shlomi-Loubaton S</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22David+E%22">David E</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Shreberk-Hassidim+R%22">Shreberk-Hassidim R</searchLink>; Dermatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Molho-Pessach+V%22">Molho-Pessach V</searchLink>; Dermatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Amar+D%22">Amar D</searchLink>; Plastic Surgery Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Tzur+T%22">Tzur T</searchLink>; Plastic Surgery Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Kuint+R%22">Kuint R</searchLink>; Institue of Pulmonology Medicine, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Gross+M%22">Gross M</searchLink>; Orthopedic Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Barboy+O%22">Barboy O</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Moshe+A%22">Moshe A</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Fellus-Alyagor+L%22">Fellus-Alyagor L</searchLink>; The Department of Veterinary Resources, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Hirsch+D%22">Hirsch D</searchLink>; The Department of Veterinary Resources, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Addadi+Y%22">Addadi Y</searchLink>; Life Sciences Core Facilities, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Erenfeld+S%22">Erenfeld S</searchLink>; Department of Bone Marrow Transplantation, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Biton+M%22">Biton M</searchLink>; Department of Biological Regulation, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Tzemach+T%22">Tzemach T</searchLink>; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Elazary+A%22">Elazary A</searchLink>; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Naparstek+Y%22">Naparstek Y</searchLink>; Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Tzemach+R%22">Tzemach R</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel; Rheumatology Institute at the Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel.<br /><searchLink fieldCode="AU" term="%22Weiner+A%22">Weiner A</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Giladi+A%22">Giladi A</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel.<br /><searchLink fieldCode="AU" term="%22Balbir-Gurman+A%22">Balbir-Gurman A</searchLink>; Rheumatology Institute, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion-Israeli Institute of Technology, Haifa, Israel.<br /><searchLink fieldCode="AU" term="%22Amit+I%22">Amit I</searchLink>; Department of Systems Immunology, Weizmann Institute, Rehovot, Israel. Electronic address: ido.amit@weizmann.ac.il.
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