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A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response.

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Title: A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response.
Authors: Hilsabeck TAU; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.; Davis School of Gerontology, University of Southern California, University Park, Los Angeles, CA, 90007, USA., Liu-Bryan R; VA San Diego Healthcare System, 111K, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA.; Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California San Diego, San Diego, CA, 92093, USA., Guo T; VA San Diego Healthcare System, 111K, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA.; Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California San Diego, San Diego, CA, 92093, USA., Wilson KA; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., Bose N; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., Raftery D; Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA., Beck JN; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.; Department of Urology, University of California, San Francisco, 400 Parnassus Avenue, Room A-632, San Francisco, CA, 94143, USA., Lang S; Department of Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany., Jin K; Allen Institute for Brain Science, Seattle, WA, 98109, USA.; Department of Pathology, University of Washington, Seattle, WA, 98195, USA., Nelson CS; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., Oron T; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA., Stoller M; Department of Urology, University of California, San Francisco, 400 Parnassus Avenue, Room A-632, San Francisco, CA, 94143, USA., Promislow D; Department of Pathology, University of Washington, Seattle, WA, 98195, USA.; Department of Biology, University of Washington, Seattle, WA, 98195, USA., Brem RB; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.; Davis School of Gerontology, University of Southern California, University Park, Los Angeles, CA, 90007, USA.; Department of Plant and Microbial Biology, University of California, Berkeley, 111 Koshland Hall, Berkeley, CA, 94720, USA., Terkeltaub R; VA San Diego Healthcare System, 111K, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA.; Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California San Diego, San Diego, CA, 92093, USA., Kapahi P; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA. pkapahi@buckinstitute.org.; Davis School of Gerontology, University of Southern California, University Park, Los Angeles, CA, 90007, USA. pkapahi@buckinstitute.org.; Department of Urology, University of California, San Francisco, 400 Parnassus Avenue, Room A-632, San Francisco, CA, 94143, USA. pkapahi@buckinstitute.org.
Source: GeroScience [Geroscience] 2022 Aug; Vol. 44 (4), pp. 2195-2211. Date of Electronic Publication: 2022 Apr 06.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response.
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  Data: <searchLink fieldCode="AU" term="%22Hilsabeck+TAU%22">Hilsabeck TAU</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.; Davis School of Gerontology, University of Southern California, University Park, Los Angeles, CA, 90007, USA.<br /><searchLink fieldCode="AU" term="%22Liu-Bryan+R%22">Liu-Bryan R</searchLink>; VA San Diego Healthcare System, 111K, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA.; Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California San Diego, San Diego, CA, 92093, USA.<br /><searchLink fieldCode="AU" term="%22Guo+T%22">Guo T</searchLink>; VA San Diego Healthcare System, 111K, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA.; Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California San Diego, San Diego, CA, 92093, USA.<br /><searchLink fieldCode="AU" term="%22Wilson+KA%22">Wilson KA</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.<br /><searchLink fieldCode="AU" term="%22Bose+N%22">Bose N</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.<br /><searchLink fieldCode="AU" term="%22Raftery+D%22">Raftery D</searchLink>; Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Beck+JN%22">Beck JN</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.; Department of Urology, University of California, San Francisco, 400 Parnassus Avenue, Room A-632, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Lang+S%22">Lang S</searchLink>; Department of Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Jin+K%22">Jin K</searchLink>; Allen Institute for Brain Science, Seattle, WA, 98109, USA.; Department of Pathology, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+CS%22">Nelson CS</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.<br /><searchLink fieldCode="AU" term="%22Oron+T%22">Oron T</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.<br /><searchLink fieldCode="AU" term="%22Stoller+M%22">Stoller M</searchLink>; Department of Urology, University of California, San Francisco, 400 Parnassus Avenue, Room A-632, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Promislow+D%22">Promislow D</searchLink>; Department of Pathology, University of Washington, Seattle, WA, 98195, USA.; Department of Biology, University of Washington, Seattle, WA, 98195, USA.<br /><searchLink fieldCode="AU" term="%22Brem+RB%22">Brem RB</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA.; Davis School of Gerontology, University of Southern California, University Park, Los Angeles, CA, 90007, USA.; Department of Plant and Microbial Biology, University of California, Berkeley, 111 Koshland Hall, Berkeley, CA, 94720, USA.<br /><searchLink fieldCode="AU" term="%22Terkeltaub+R%22">Terkeltaub R</searchLink>; VA San Diego Healthcare System, 111K, 3350 La Jolla Village Drive, San Diego, CA, 92161, USA.; Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California San Diego, San Diego, CA, 92093, USA.<br /><searchLink fieldCode="AU" term="%22Kapahi+P%22">Kapahi P</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA. pkapahi@buckinstitute.org.; Davis School of Gerontology, University of Southern California, University Park, Los Angeles, CA, 90007, USA. pkapahi@buckinstitute.org.; Department of Urology, University of California, San Francisco, 400 Parnassus Avenue, Room A-632, San Francisco, CA, 94143, USA. pkapahi@buckinstitute.org.
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