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Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.

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Title: Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.
Authors: Nakao T; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Bick AG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA., Taub MA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Zekavat SM; Yale University School of Medicine, New Haven, CT, USA., Uddin MM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Niroula A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Laboratory Medicine, Lund University, Lund, Sweden., Carty CL; Initiative for Research and Education to Advance Community Health, Washington State University, Seattle, WA, USA., Lane J; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Honigberg MC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Weinstock JS; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Pampana A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Gibson CJ; Department of Medicine, Harvard Medical School, Boston, MA, USA., Griffin GK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Clarke SL; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Bhattacharya R; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA., Assimes TL; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Emery LS; Department of Biostatistics, University of Washington, Seattle, WA, USA., Stilp AM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Wong Q; Department of Biostatistics, University of Washington, Seattle, WA, USA., Broome J; Department of Biostatistics, University of Washington, Seattle, WA, USA., Laurie CA; Department of Biostatistics, University of Washington, Seattle, WA, USA., Khan AT; Department of Biostatistics, University of Washington, Seattle, WA, USA., Smith AV; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Blackwell TW; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Codd V; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Yoneda ZT; Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA., Peralta JM; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Irvin MR; Department of Biostatistics, School of Public Health, University of Alabama, Birmingham, AL, USA., Boorgula M; Division of Biomedical Informatics and Personalized Medicine and the Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Yanek LR; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Wiggins KL; Department of Medicine, University of Washington, Seattle, WA, USA., Hixson JE; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Gu CC; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Roden DM; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Reupena MS; Ministry of Health, Government of Samoa, Apia, Samoa., Hwu CM; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan., DeMeo DL; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Kelly S; Vitalant Research Institute, San Francisco, CA, USA.; UCSF, Benioff Children's Hospital Oakland, Oakland, CA, USA., Musani SK; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Lloyd-Jones DM; Division of Cardiology Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Johnsen JM; Bloodworks Northwest Research Institute, Seattle, WA, USA., Preuss M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tracy RP; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Pathology and Biochemistry, University of Vermont College of Medicine, Burlington, VT, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Qiao D; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Desai P; Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY, USA., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Freedman BI; Internal Medicine-Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Tiwari HK; Department of Epidemiology, School of Public Health, University of Alabama, Birmingham, AL, USA., Chavan S; Division of Biomedical Informatics and Personalized Medicine and the Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA., Kelly TN; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.; Tulane University Translational Science Institute, New Orleans, LA, USA., Hidalgo B; Department of Epidemiology, School of Public Health, University of Alabama, Birmingham, AL, USA., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; National Heart Lung and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA., Weeks DE; Department of Human Genetics and Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA., Hawley NL; Department of Chronic Disease Epidemiology, Yale University, New Haven, CT, USA., Minster RL; Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA., Deka R; Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA.; Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Naseri TT; Department of Health, American Samoa Government, Pago Pago, American Samoa, USA., de las Fuentes L; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Raffield LM; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Vries PS; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Ballantyne CM; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Kenny EE; Institute for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Whitsel EA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Cho MH; Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Shoemaker MB; Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA., Pace BS; Division of Hematology/Oncology, Department of Pediatrics, Augusta University, Augusta, GA, USA., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Shuldiner AR; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA., Barnes KC; Division of Biomedical Informatics and Personalized Medicine and the Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA., Redline S; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Abecasis GR; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Becker LC; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Heckbert SR; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., He J; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.; Tulane University Translational Science Institute, New Orleans, LA, USA., Post W; Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA., Arnett DK; Dean's Office, College of Public Health, University of Kentucky, Lexington, KY, USA., Vasan RS; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; National Heart Lung and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.; Departments of Cardiology and Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Darbar D; Division of Cardiology, University of Illinois at Chicago, Chicago, IL, USA., Weiss ST; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., McGarvey ST; Department of Epidemiology and International Health Institute, Brown University School of Public Health, Providence, RI, USA., de Andrade M; Mayo Clinic, Department of Health Sciences Research, Rochester, MN, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA., Meyers DA; Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA., Custer BS; Vitalant Research Institute, San Francisco, CA, USA., Correa A; Departments of Medicine and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA., Fornage M; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Manson JE; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Boerwinkle E; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Konkle BA; Department of Medicine, University of Washington, Seattle, WA, USA.; Bloodworks Northwest, Seattle, WA, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Silverman EK; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Kooperberg C; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Jaiswal S; Department of Pathology, Stanford University, Stanford, CA, USA., Libby P; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Ellinor PT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA., Ebert BL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA., Reiner AP; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Mathias RA; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Do R; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Natarajan P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
Corporate Authors: Samoan Obesity, Lifestyle and Genetic Adaptations Study (OLaGA) Group, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Source: Science advances [Sci Adv] 2022 Apr 08; Vol. 8 (14), pp. eabl6579. Date of Electronic Publication: 2022 Apr 06.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE; PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Nakao+T%22">Nakao T</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bick+AG%22">Bick AG</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Taub+MA%22">Taub MA</searchLink>; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zekavat+SM%22">Zekavat SM</searchLink>; Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Uddin+MM%22">Uddin MM</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Niroula+A%22">Niroula A</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Laboratory Medicine, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Carty+CL%22">Carty CL</searchLink>; Initiative for Research and Education to Advance Community Health, Washington State University, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Lane+J%22">Lane J</searchLink>; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Honigberg+MC%22">Honigberg MC</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Weinstock+JS%22">Weinstock JS</searchLink>; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Pampana+A%22">Pampana A</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gibson+CJ%22">Gibson CJ</searchLink>; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Griffin+GK%22">Griffin GK</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Clarke+SL%22">Clarke SL</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bhattacharya+R%22">Bhattacharya R</searchLink>; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Assimes+TL%22">Assimes TL</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA.<br /><searchLink fieldCode="AU" term="%22Emery+LS%22">Emery LS</searchLink>; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Stilp+AM%22">Stilp AM</searchLink>; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Wong+Q%22">Wong Q</searchLink>; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Broome+J%22">Broome J</searchLink>; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Laurie+CA%22">Laurie CA</searchLink>; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Khan+AT%22">Khan AT</searchLink>; Department of Biostatistics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+AV%22">Smith AV</searchLink>; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Blackwell+TW%22">Blackwell TW</searchLink>; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Codd+V%22">Codd V</searchLink>; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Nelson+CP%22">Nelson CP</searchLink>; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Yoneda+ZT%22">Yoneda ZT</searchLink>; Division of Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Peralta+JM%22">Peralta JM</searchLink>; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bowden+DW%22">Bowden DW</searchLink>; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.<br /><searchLink fieldCode="AU" term="%22Irvin+MR%22">Irvin MR</searchLink>; Department of Biostatistics, School of Public Health, University of Alabama, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Boorgula+M%22">Boorgula M</searchLink>; Division of Biomedical Informatics and Personalized Medicine and the Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Yanek+LR%22">Yanek LR</searchLink>; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wiggins+KL%22">Wiggins KL</searchLink>; Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hixson+JE%22">Hixson JE</searchLink>; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Gu+CC%22">Gu CC</searchLink>; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Peloso+GM%22">Peloso GM</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Roden+DM%22">Roden DM</searchLink>; Departments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Reupena+MS%22">Reupena MS</searchLink>; Ministry of Health, Government of Samoa, Apia, Samoa.<br /><searchLink fieldCode="AU" term="%22Hwu+CM%22">Hwu CM</searchLink>; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22DeMeo+DL%22">DeMeo DL</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22North+KE%22">North KE</searchLink>; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kelly+S%22">Kelly S</searchLink>; Vitalant Research Institute, San Francisco, CA, USA.; UCSF, Benioff Children's Hospital Oakland, Oakland, CA, USA.<br /><searchLink fieldCode="AU" term="%22Musani+SK%22">Musani SK</searchLink>; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.<br /><searchLink fieldCode="AU" term="%22Bis+JC%22">Bis JC</searchLink>; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Lloyd-Jones+DM%22">Lloyd-Jones DM</searchLink>; Division of Cardiology Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Johnsen+JM%22">Johnsen JM</searchLink>; Bloodworks Northwest Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Preuss+M%22">Preuss M</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tracy+RP%22">Tracy RP</searchLink>; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Pathology and Biochemistry, University of Vermont College of Medicine, Burlington, VT, USA.<br /><searchLink fieldCode="AU" term="%22Peyser+PA%22">Peyser PA</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Qiao+D%22">Qiao D</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Desai+P%22">Desai P</searchLink>; Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Curran+JE%22">Curran JE</searchLink>; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.<br /><searchLink fieldCode="AU" term="%22Freedman+BI%22">Freedman BI</searchLink>; Internal Medicine-Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.<br /><searchLink fieldCode="AU" term="%22Tiwari+HK%22">Tiwari HK</searchLink>; Department of Epidemiology, School of Public Health, University of Alabama, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Chavan+S%22">Chavan S</searchLink>; Division of Biomedical Informatics and Personalized Medicine and the Colorado Center for Personalized Medicine, School of Medicine, University of Colorado, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Smith+JA%22">Smith JA</searchLink>; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Smith+NL%22">Smith NL</searchLink>; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kelly+TN%22">Kelly TN</searchLink>; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.; Tulane University Translational Science Institute, New Orleans, LA, USA.<br /><searchLink fieldCode="AU" term="%22Hidalgo+B%22">Hidalgo B</searchLink>; Department of Epidemiology, School of Public Health, University of Alabama, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Cupples+LA%22">Cupples LA</searchLink>; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; National Heart Lung and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Weeks+DE%22">Weeks DE</searchLink>; Department of Human Genetics and Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hawley+NL%22">Hawley NL</searchLink>; 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Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Boerwinkle+E%22">Boerwinkle E</searchLink>; Center for Statistical Genetics, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Konkle+BA%22">Konkle BA</searchLink>; Department of Medicine, University of Washington, Seattle, WA, USA.; Bloodworks Northwest, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Loos+RJF%22">Loos RJF</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rotter+JI%22">Rotter JI</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.<br /><searchLink fieldCode="AU" term="%22Silverman+EK%22">Silverman EK</searchLink>; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kooperberg+C%22">Kooperberg C</searchLink>; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Danesh+J%22">Danesh J</searchLink>; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Samani+NJ%22">Samani NJ</searchLink>; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Jaiswal+S%22">Jaiswal S</searchLink>; Department of Pathology, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Libby+P%22">Libby P</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ellinor+PT%22">Ellinor PT</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pankratz+N%22">Pankratz N</searchLink>; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Ebert+BL%22">Ebert BL</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Reiner+AP%22">Reiner AP</searchLink>; Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mathias+RA%22">Mathias RA</searchLink>; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Do+R%22">Do R</searchLink>; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Natarajan+P%22">Natarajan P</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%22101653440%22">Science advances</searchLink> [Sci Adv] 2022 Apr 08; Vol. 8 (14), pp. eabl6579. <i>Date of Electronic Publication: </i>2022 Apr 06.
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      – TitleFull: Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.
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          Dates:
            – D: 08
              M: 04
              Text: 2022 Apr 08
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 2375-2548
          Numbering:
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              Value: 8
            – Type: issue
              Value: 14
          Titles:
            – TitleFull: Science advances
              Type: main
ResultId 1