Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C.

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Title: Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C.
Authors: Zhao M; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Ren K; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA; College of Medicine, Hunan Normal University, Changsha, Hunan, China., Xiong X; School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Xin Y; School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Zou Y; MOE Key Laboratory of Model Animals for Disease Study, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China., Maynard JC; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA., Kim A; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Battist AP; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Koneripalli N; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Wang Y; MOE Key Laboratory of Model Animals for Disease Study, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China., Chen Q; MOE Key Laboratory of Model Animals for Disease Study, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China., Xin R; MOE Key Laboratory of Model Animals for Disease Study, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China., Yang C; School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Huang R; School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Yu J; School of Forensic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Huang Z; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Zhang Z; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Wang H; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Wang D; College of Medicine, Hunan Normal University, Changsha, Hunan, China., Xiao Y; College of Medicine, Hunan Normal University, Changsha, Hunan, China., Salgado OC; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Jarjour NN; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Hogquist KA; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA., Revelo XS; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA., Burlingame AL; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, USA., Gao X; MOE Key Laboratory of Model Animals for Disease Study, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China., von Moltke J; Department of Immunology, University of Washington School of Medicine, Seattle, Washington, USA., Lin Z; MOE Key Laboratory of Model Animals for Disease Study, State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, China. Electronic address: linzy@nju.edu.cn., Ruan HB; Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA; Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA. Electronic address: hruan@umn.edu.
Source: Immunity [Immunity] 2022 Apr 12; Vol. 55 (4), pp. 623-638.e5. Date of Electronic Publication: 2022 Apr 05.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-4180
DOI:10.1016/j.immuni.2022.03.009