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Rare coding variants in ten genes confer substantial risk for schizophrenia.

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Title: Rare coding variants in ten genes confer substantial risk for schizophrenia.
Authors: Singh T; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. tsingh@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. tsingh@broadinstitute.org.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. tsingh@broadinstitute.org., Poterba T; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Curtis D; UCL Genetics Institute, University College London, London, UK.; Centre for Psychiatry, Queen Mary University London, London, UK., Akil H; Department of Psychiatry, Michigan Neuroscience Institute, Medical School, University of Michigan, Ann Arbor, MI, USA., Al Eissa M; Division of Psychiatry, University College London, London, UK., Barchas JD; Weill Cornell Medical College, New York, NY, USA., Bass N; Division of Psychiatry, University College London, London, UK., Bigdeli TB; Department of Psychiatry and Behavioral Sciences, SUNY Downstate College of Medicine, Brooklyn, NY, USA., Breen G; Social Genetic and Developmental Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Bromet EJ; Department of Psychiatry and Behavioral Health, Health Sciences Center, Stony Brook University, Stony Brook, NY, USA., Buckley PF; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Bunney WE; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA., Bybjerg-Grauholm J; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Byerley WF; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA., Chapman SB; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chen WJ; College of Public Health, National Taiwan University, Taipei, Taiwan., Churchhouse C; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Craddock N; National Centre for Mental Health, Cardiff University, Cardiff, UK., Cusick CM; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., DeLisi L; Department of Psychiatry, Cambridge Health Alliance, Cambridge Hospital, Cambridge, MA, USA., Dodge S; Genomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Escamilla MA; Texas Tech University Health Sciences Center, El Paso, TX, USA., Eskelinen S; University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland., Fanous AH; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA., Faraone SV; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA., Fiorentino A; Division of Psychiatry, University College London, London, UK., Francioli L; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Gabriel SB; Genomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gage D; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gagliano Taliun SA; Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada.; Montréal Heart Institute, Montreal, Quebec, Canada., Ganna A; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Genovese G; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Glahn DC; Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA., Grove J; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Department of Biomedicine and Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; Center for Genomics and Personalized Medicine, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark., Hall MH; McLean Hospital, Harvard Medical School, Belmont, MA, USA., Hämäläinen E; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Heyne HO; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Holi M; Department of Psychiatry, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Hougaard DM; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Howrigan DP; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huang H; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hwu HG; Department of Psychiatry, National Taiwan University, Taipei, Taiwan., Kahn RS; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; MIRECC, JP Peters VA Hospital, Bronx, NY, USA., Kang HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Karczewski KJ; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kirov G; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Knowles JA; Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY, USA., Lee FS; Weill Cornell Medical College, New York, NY, USA., Lehrer DS; Department of Psychiatry, Wright State University, Dayton, OH, USA., Lescai F; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Malaspina D; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Marder SR; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., McCarroll SA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., McIntosh AM; University of Edinburgh, Edinburgh, UK., Medeiros H; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA., Milani L; Institute of Genomics, University of Tartu, Tartu, Estonia., Morley CP; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Public Health and Preventive Medicine and Department of Family Medicine, SUNY Upstate Medical University, Syracuse, NY, USA., Morris DW; National University of Ireland, Galway, Ireland., Mortensen PB; Aarhus University, Aarhus, Denmark., Myers RM; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA., Nordentoft M; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Copenhagen Research Center for Mental Health, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., O'Brien NL; Division of Psychiatry, University College London, London, UK., Olivares AM; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ongur D; McLean Hospital, Harvard Medical School, Belmont, MA, USA., Ouwehand WH; University of Cambridge, Cambridge, UK., Palmer DS; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Paunio T; Department of Psychiatry, University of Helsinki, Helsinki, Finland., Quested D; Oxford Health NHS Foundation Trust, Oxford, UK., Rapaport MH; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA., Rees E; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Rollins B; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA., Satterstrom FK; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA., Schatzberg A; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Scolnick E; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Sharp SI; Division of Psychiatry, University College London, London, UK., Sklar P; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Smoller JW; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Sobell JL; Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Solomonson M; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Stahl EA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Stevens CR; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Suvisaari J; Finnish Institute for Health and Welfare, Helsinki, Finland., Tiao G; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Watson SJ; Department of Psychiatry, Michigan Neuroscience Institute, Medical School, University of Michigan, Ann Arbor, MI, USA., Watts NA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Blackwood DH; Department of Psychiatry, University of Edinburgh, Edinburgh, UK., Børglum AD; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Department of Biomedicine and Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; Center for Genomics and Personalized Medicine, Aarhus, Denmark., Cohen BM; McLean Hospital, Harvard Medical School, Belmont, MA, USA., Corvin AP; Trinity College Dublin, Dublin, Ireland., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia., Freimer NB; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Glatt SJ; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA., Hultman CM; School of Medicine, Johns Hopkins University, Baltimore, MD, USA., McQuillin A; Division of Psychiatry, University College London, London, UK., Palotie A; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA., Pato CN; Department of Psychiatry and Behavioral Sciences, SUNY Downstate College of Medicine, Brooklyn, NY, USA., Pato MT; Department of Psychiatry and Behavioral Sciences, SUNY Downstate College of Medicine, Brooklyn, NY, USA., Pulver AE; School of Medicine, Johns Hopkins University, Baltimore, MD, USA., St Clair D; University of Aberdeen, Aberdeen, UK., Tsuang MT; Center for Behavioral Genomics, Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA., Vawter MP; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA., Walters JT; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Werge TM; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark.; Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark., Ophoff RA; Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry, Erasmus Medical Center, Erasmus University, Rotterdam, the Netherlands., Sullivan PF; Karolinska Institute, Solna, Sweden.; University of North Carolina, Chapel Hill, NC, USA., Owen MJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., O'Donovan MC; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Neale BM; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. bneale@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. bneale@broadinstitute.org.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. bneale@broadinstitute.org., Daly MJ; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland. mjdaly@atgu.mgh.harvard.edu.
Source: Nature [Nature] 2022 Apr; Vol. 604 (7906), pp. 509-516. Date of Electronic Publication: 2022 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Rare coding variants in ten genes confer substantial risk for schizophrenia.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Singh+T%22">Singh T</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. tsingh@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. tsingh@broadinstitute.org.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. tsingh@broadinstitute.org.<br /><searchLink fieldCode="AU" term="%22Poterba+T%22">Poterba T</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Curtis+D%22">Curtis D</searchLink>; UCL Genetics Institute, University College London, London, UK.; Centre for Psychiatry, Queen Mary University London, London, UK.<br /><searchLink fieldCode="AU" term="%22Akil+H%22">Akil H</searchLink>; Department of Psychiatry, Michigan Neuroscience Institute, Medical School, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Al+Eissa+M%22">Al Eissa M</searchLink>; Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Barchas+JD%22">Barchas JD</searchLink>; Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bass+N%22">Bass N</searchLink>; Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bigdeli+TB%22">Bigdeli TB</searchLink>; Department of Psychiatry and Behavioral Sciences, SUNY Downstate College of Medicine, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Breen+G%22">Breen G</searchLink>; Social Genetic and Developmental Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bromet+EJ%22">Bromet EJ</searchLink>; Department of Psychiatry and Behavioral Health, Health Sciences Center, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Buckley+PF%22">Buckley PF</searchLink>; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Bunney+WE%22">Bunney WE</searchLink>; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bybjerg-Grauholm+J%22">Bybjerg-Grauholm J</searchLink>; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Byerley+WF%22">Byerley WF</searchLink>; Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chapman+SB%22">Chapman SB</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+WJ%22">Chen WJ</searchLink>; College of Public Health, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Churchhouse+C%22">Churchhouse C</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Craddock+N%22">Craddock N</searchLink>; National Centre for Mental Health, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Cusick+CM%22">Cusick CM</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22DeLisi+L%22">DeLisi L</searchLink>; Department of Psychiatry, Cambridge Health Alliance, Cambridge Hospital, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dodge+S%22">Dodge S</searchLink>; Genomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Escamilla+MA%22">Escamilla MA</searchLink>; Texas Tech University Health Sciences Center, El Paso, TX, USA.<br /><searchLink fieldCode="AU" term="%22Eskelinen+S%22">Eskelinen S</searchLink>; University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Public Health Solutions, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Fanous+AH%22">Fanous AH</searchLink>; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Faraone+SV%22">Faraone SV</searchLink>; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fiorentino+A%22">Fiorentino A</searchLink>; Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Francioli+L%22">Francioli L</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gabriel+SB%22">Gabriel SB</searchLink>; Genomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gage+D%22">Gage D</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gagliano+Taliun+SA%22">Gagliano Taliun SA</searchLink>; Faculté de Médecine, Université de Montréal, Montreal, Quebec, Canada.; Montréal Heart Institute, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Ganna+A%22">Ganna A</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Genovese+G%22">Genovese G</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Glahn+DC%22">Glahn DC</searchLink>; Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Grove+J%22">Grove J</searchLink>; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Department of Biomedicine and Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; Center for Genomics and Personalized Medicine, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Hall+MH%22">Hall MH</searchLink>; McLean Hospital, Harvard Medical School, Belmont, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hämäläinen+E%22">Hämäläinen E</searchLink>; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Heyne+HO%22">Heyne HO</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Holi+M%22">Holi M</searchLink>; Department of Psychiatry, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Hougaard+DM%22">Hougaard DM</searchLink>; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Howrigan+DP%22">Howrigan DP</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hwu+HG%22">Hwu HG</searchLink>; Department of Psychiatry, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kahn+RS%22">Kahn RS</searchLink>; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; MIRECC, JP Peters VA Hospital, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kang+HM%22">Kang HM</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Karczewski+KJ%22">Karczewski KJ</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kirov+G%22">Kirov G</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Knowles+JA%22">Knowles JA</searchLink>; Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lee+FS%22">Lee FS</searchLink>; Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lehrer+DS%22">Lehrer DS</searchLink>; Department of Psychiatry, Wright State University, Dayton, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lescai+F%22">Lescai F</searchLink>; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Malaspina+D%22">Malaspina D</searchLink>; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Marder+SR%22">Marder SR</searchLink>; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22McCarroll+SA%22">McCarroll SA</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22McIntosh+AM%22">McIntosh AM</searchLink>; University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Medeiros+H%22">Medeiros H</searchLink>; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Milani+L%22">Milani L</searchLink>; Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Morley+CP%22">Morley CP</searchLink>; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.; Department of Public Health and Preventive Medicine and Department of Family Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.<br /><searchLink fieldCode="AU" term="%22Morris+DW%22">Morris DW</searchLink>; National University of Ireland, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Mortensen+PB%22">Mortensen PB</searchLink>; Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Myers+RM%22">Myers RM</searchLink>; HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.<br /><searchLink fieldCode="AU" term="%22Nordentoft+M%22">Nordentoft M</searchLink>; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Copenhagen Research Center for Mental Health, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22O'Brien+NL%22">O'Brien NL</searchLink>; Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Olivares+AM%22">Olivares AM</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ongur+D%22">Ongur D</searchLink>; McLean Hospital, Harvard Medical School, Belmont, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ouwehand+WH%22">Ouwehand WH</searchLink>; University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Palmer+DS%22">Palmer DS</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Paunio+T%22">Paunio T</searchLink>; Department of Psychiatry, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Quested+D%22">Quested D</searchLink>; Oxford Health NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rapaport+MH%22">Rapaport MH</searchLink>; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Rees+E%22">Rees E</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Rollins+B%22">Rollins B</searchLink>; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Satterstrom+FK%22">Satterstrom FK</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schatzberg+A%22">Schatzberg A</searchLink>; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Scolnick+E%22">Scolnick E</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Scott+LJ%22">Scott LJ</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Sharp+SI%22">Sharp SI</searchLink>; Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sklar+P%22">Sklar P</searchLink>; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Smoller+JW%22">Smoller JW</searchLink>; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sobell+JL%22">Sobell JL</searchLink>; Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Solomonson+M%22">Solomonson M</searchLink>; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stahl+EA%22">Stahl EA</searchLink>; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Stevens+CR%22">Stevens CR</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Suvisaari+J%22">Suvisaari J</searchLink>; Finnish Institute for Health and Welfare, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Tiao+G%22">Tiao G</searchLink>; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Watson+SJ%22">Watson SJ</searchLink>; Department of Psychiatry, Michigan Neuroscience Institute, Medical School, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Watts+NA%22">Watts NA</searchLink>; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Blackwood+DH%22">Blackwood DH</searchLink>; Department of Psychiatry, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Børglum+AD%22">Børglum AD</searchLink>; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Department of Biomedicine and Center for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; Center for Genomics and Personalized Medicine, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Cohen+BM%22">Cohen BM</searchLink>; McLean Hospital, Harvard Medical School, Belmont, MA, USA.<br /><searchLink fieldCode="AU" term="%22Corvin+AP%22">Corvin AP</searchLink>; Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Esko+T%22">Esko T</searchLink>; Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Freimer+NB%22">Freimer NB</searchLink>; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Glatt+SJ%22">Glatt SJ</searchLink>; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hultman+CM%22">Hultman CM</searchLink>; School of Medicine, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22McQuillin+A%22">McQuillin A</searchLink>; Division of Psychiatry, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Palotie+A%22">Palotie A</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pato+CN%22">Pato CN</searchLink>; Department of Psychiatry and Behavioral Sciences, SUNY Downstate College of Medicine, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pato+MT%22">Pato MT</searchLink>; Department of Psychiatry and Behavioral Sciences, SUNY Downstate College of Medicine, Brooklyn, NY, USA.<br /><searchLink fieldCode="AU" term="%22Pulver+AE%22">Pulver AE</searchLink>; School of Medicine, Johns Hopkins University, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22St+Clair+D%22">St Clair D</searchLink>; University of Aberdeen, Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Tsuang+MT%22">Tsuang MT</searchLink>; Center for Behavioral Genomics, Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vawter+MP%22">Vawter MP</searchLink>; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Walters+JT%22">Walters JT</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Werge+TM%22">Werge TM</searchLink>; Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark.; Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Ophoff+RA%22">Ophoff RA</searchLink>; Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry, Erasmus Medical Center, Erasmus University, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Sullivan+PF%22">Sullivan PF</searchLink>; Karolinska Institute, Solna, Sweden.; University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Owen+MJ%22">Owen MJ</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Boehnke+M%22">Boehnke M</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22O'Donovan+MC%22">O'Donovan MC</searchLink>; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Neale+BM%22">Neale BM</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. bneale@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. bneale@broadinstitute.org.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. bneale@broadinstitute.org.<br /><searchLink fieldCode="AU" term="%22Daly+MJ%22">Daly MJ</searchLink>; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland. mjdaly@atgu.mgh.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2022 Apr; Vol. 604 (7906), pp. 509-516. <i>Date of Electronic Publication: </i>2022 Apr 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0410462 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4687 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200280836%22">00280836 </searchLink><i>NLM ISO Abbreviation: </i>Nature <i>Subsets: </i>MEDLINE
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      – TitleFull: Rare coding variants in ten genes confer substantial risk for schizophrenia.
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          Name:
            NameFull: Vawter MP
      – PersonEntity:
          Name:
            NameFull: Walters JT
      – PersonEntity:
          Name:
            NameFull: Werge TM
      – PersonEntity:
          Name:
            NameFull: Ophoff RA
      – PersonEntity:
          Name:
            NameFull: Sullivan PF
      – PersonEntity:
          Name:
            NameFull: Owen MJ
      – PersonEntity:
          Name:
            NameFull: Boehnke M
      – PersonEntity:
          Name:
            NameFull: O'Donovan MC
      – PersonEntity:
          Name:
            NameFull: Neale BM
      – PersonEntity:
          Name:
            NameFull: Daly MJ
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: 2022 Apr
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Numbering:
            – Type: volume
              Value: 604
            – Type: issue
              Value: 7906
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1