| Authors: |
Vitkova M; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Diouf I; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Malpas C; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Horakova D; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Kubala Havrdova E; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Patti F; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Ozakbas S; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Izquierdo G; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Eichau S; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Shaygannejad V; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Onofrj M; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Lugaresi A; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Alroughani R; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Prat A; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Larochelle C; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Girard M; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Duquette P; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Terzi M; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Boz C; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Grand'Maison F; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Sola P; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Ferraro D; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Grammond P; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Butzkueven H; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Buzzard K; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Skibina O; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Yamout BI; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Karabudak R; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Gerlach O; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Lechner-Scott J; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Maimone D; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Bergamaschi R; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Van Pesch V; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Iuliano G; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Cartechini E; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., José Sà M; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Ampapa R; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Barnett M; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Hughes SE; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Ramo-Tello CM; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Hodgkinson S; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Spitaleri DLA; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Petersen T; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Butler EG; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Slee M; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., McGuigan C; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., McCombe PA; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Granella F; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Cristiano E; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Prevost J; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Taylor BV; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Sãnchez-Menoyo JL; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Laureys G; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Van Hijfte L; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Vucic S; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Macdonell RA; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Gray O; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Olascoaga J; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Deri N; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Fragoso YD; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Shaw C; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia., Kalincik T; From the CORe (M.V., I.D., C.M., P.D.M.P., T.K.), Department of Medicine, University of Melbourne, Australia; Melbourne MS Centre (M.V.), Department of Neurology, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia; Melbourne MS Centre (P.D.M.P., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia; Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic; Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia; Multiple Sclerosis Center (F.P.), University of Catania, Italy; Dokuz Eylul University (S.O.), Konak/Izmir, Turkey; Hospital Universitario Virgen Macarena (G. Izquierdo, S.E.), Sevilla, Spain; Isfahan Neurosciences Research Center (INRC) (V.S.), Isfahan University of Medical Sciences (IUMS), Iran; Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. D'Annunzio, Chieti; IRCCS Istituto Delle Scienze Neurologiche di Bologna (A.L.); Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Universita di Bologna, Italy; Division of Neurology (R. Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait; CHUM MS Center and Universite de Montreal (A.P., C.L., M.G., P.D.), Quebec, Canada; Medical Faculty (M.T.), Ondokuz Mayis University, Samsun; KTU Medical Faculty Farabi Hospital (C. Boz), Trabzon, Turkey; Neuro Rive-Sud (F.G.), Longueuil, Quebec, Canada; Azienda Ospedaliera Universitaria di Modena (P.S.); Department of Biomedical (D.F.), Metabolic and Neurosciences, University of Modena and Reggio Emilia, Italy; CISSS Chaudière-Appalache (P.G.), Levis, Quebec, Canada; Central Clinical School (H.B.), Monash University; Department of Neurology (H.B., O.S.), The Alfred Hospital; Department of Neurology (K.B., O.S.), Box Hill Hospital, Eastern Health; Monash University (K.B., O.S.), Melbourne, Australia; Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y.), American University of Beirut Medical Center, Lebanon; Hacettepe University (R.K.), Ankara, Turkey; Zuyderland Medical Centre (O. Gerlach), Department of Neurologie, Dr. H. van der Hoffplein 1, Sittard-Geleen, the Netherlands; School of Medicine and Public Health (J.L.-S.), University Newcastle; Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia; MS Center (D.M.), Neurology Unit, Garibaldi Hospital, Catania; IRCCS Mondino Foundation (R.B.), Pavia, Italy; Cliniques Universitaires Saint-Luc (V.V.P.), Brussels; Université Catholique de Louvain (V.V.P.), Belgium; Ospedali Riuniti di Salerno (G. Iuliano); UOC Neurologia (E. Cartechini), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy; Hospital de Sao Joao (M.J.S.), Universidade Fernando Pessoa, Porto, Portugal; Nemocnice Jihlava (R. Ampapa), Jihlava, Czech Republic; Brain and Mind Centre (M.B.), Sydney, Australia; Royal Victoria Hospital (S.E.H.), Belfast, UK; Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain; Liverpool Hospital (S.H.), Sydney, Australia; Liverpool Hospital and Ingham Institute (S.H.), Australia; Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy; Kommunehospitalet (T.P.), Aarhus, Denmark; Monash Medical Centre (E.G.B.), Melbourne; Flinders University (M.S.), Adelaide, Australia; University College Dublin and St. Vincent's University Hospital (C. McGuigan), Ireland; University of Queensland (P.A.M.); Royal Brisbane and Women's Hospital (P.A.M.), Australia; Department of Medicine and Surgery (F.G.), University of Parma; Department of Emergency and General Medicine (F.G.), Parma University Hospital, Italy; Hospital Italiano (E. Cristiano), Buenos Aires, Argentina; CSSS Saint-Jérôme (J.P.), Saint-Jerome, Quebec, Canada; Royal Hobart Hospital (B.V.T.), Australia; Hospital de Galdakao-Usansolo (J.L.S.Ã.-M.), Galdakao, Spain; Department of Neurology (G.L.), Ghent University Hospital, Corneel Heymanslaan 10; University Hospital Ghent (L.V.H.), Ghent, Belgium; Westmead Hospital (S.V.), Sydney; Austin Health (R.A.M.), Melbourne, Australia; South East Trust (O. Gray), Belfast, UK; Instituto de Investigación Sanitaria Biodonostia (J.O.), Hospital Universitario Donostia, San Sebastián, Spain; Hospital Fernandez (N.D.), Capital Federal, Argentina; Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil; and Geelong Hospital (C.S.), Geelong, Australia. tomas.kalincik@unimelb.edu.au. |
