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Lessening Organ Dysfunction With Vitamin C (LOVIT) Trial: Statistical Analysis Plan.

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Title: Lessening Organ Dysfunction With Vitamin C (LOVIT) Trial: Statistical Analysis Plan.
Authors: Adhikari NK; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada., Pinto R; Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Day AG; Kingston Health Sciences Centre, Kingston, ON, Canada.; Department of Public Health Sciences, Queen's University, Kingston, ON, Canada., Masse MH; Research Centre of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada., Ménard J; Research Centre of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada., Sprague S; Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada., Annane D; Department of Intensive Care Medicine, Raymond-Poincaré Hospital (Assistance Publique - Hôpitaux de Paris [AP-HP]), Garches, France.; Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay Campus Université de Versailles Saint-Quentin-en-Yvelines, Versailles, France.; Fédération Hospitalo-Universitaire SEPSIS, Garches, France., Arabi YM; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; Department of Intensive Care, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia., Battista MC; Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada., Cohen D; Bishop's University, Sherbroooke, QC, Canada.; Massawippi Valley Foundation, Ayer's Cliff, QC, Canada., Cook DJ; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Department of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada., Guyatt GH; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada., Heyland DK; Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.; Kingston General Health Research Institute, Kingston Health Sciences Centre, Kingston, ON, Canada.; Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, ON, Canada., Kanji S; The Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Pharmacy, The Ottawa Hospital, Ottawa, ON, Canada., McGuinness SP; Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand.; Medical Research Institute of New Zealand, Newtown, New Zealand.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia., Parke RL; Cardiothoracic and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand.; Medical Research Institute of New Zealand, Newtown, New Zealand.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.; School of Nursing, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Tirupakuzhi Vijayaraghavan BK; Department of Critical Care Medicine, Apollo Hospitals, Chennai, India.; The George Institute for Global Health, New Delhi, India., Charbonney E; Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.; Centre de Recherche de l'Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada., Chassé M; Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.; Department of Medicine, Université de Montréal, Montréal, QC, Canada., Del Sorbo L; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.; Department of Medicine, University Health Network, Toronto, ON, Canada., Kutsogiannis DJ; Department of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada., Lauzier F; Department of Medicine, Université Laval, Québec, QC, Canada.; Department of Anesthesiology and Critical Care, Université Laval, Québec, QC, Canada.; Population Health and Optimal Health Practices Research Unit, Traumatology - Emergency - Critical Care Medicine, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Centre Hospitalier Universitaire de Québec - Université Laval, Québec, QC, Canada.; Critical Care Medicine Service, Centre Hospitalier Universitaire de Québec - Université Laval, Quebec, QC, Canada., Leblanc R; Department of Medicine, Centre Hospitalier Universitaire Dr Georges-L. Dumont, Moncton, NB, Canada.; Division of Intensive Care, Centre Hospitalier Universitaire Dr Georges-L. Dumont, Moncton, NB, Canada., Maslove DM; Kingston Health Sciences Centre, Kingston, ON, Canada.; Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.; Department of Medicine, Queen's University, Kingston, ON, Canada., Mehta S; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.; Sinai Health System, Toronto, ON, Canada., Mekontso Dessap A; Service de Médecine Intensive Réanimation, Assistance Publique - Hôpitaux de Paris [AP-HP], Hôpitaux Universitaires Henri-Mondor, Créteil, France.; Groupe de Recherche Clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis), Université de Paris Est Créteil, Créteil, France.; Institut Mondor de Recherche Biomédicale, Institut National de la Santé et de la Recherche Médicale, Université Paris Est Créteil, Créteil, France., Mele TS; Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Rochwerg B; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada., Rewa OG; Department of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada., Shahin J; Department of Medicine, McGill University Health Centre, Montréal, QC, Canada.; Department of Critical Care, McGill University Health Centre, Montréal, QC, Canada., Twardowski P; Department of Surgical Sciences, University of Otago, Dunedin, New Zealand., Young PJ; Medical Research Institute of New Zealand, Newtown, New Zealand.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia.; Intensive Care Unit, Wellington Hospital, Newton, New Zealand., Lamontagne F; Research Centre of the Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.; Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada.
Corporate Authors: LOVIT Investigators; See Acknowledgements, , .
Source: JMIR research protocols [JMIR Res Protoc] 2022 May 20; Vol. 11 (5), pp. e36261. Date of Electronic Publication: 2022 May 20.
Publication Type: Journal Article
Journal Info: Publisher: JMIR Publications Country of Publication: Canada NLM ID: 101599504 Publication Model: Electronic Cited Medium: Print ISSN: 1929-0748 (Print) Linking ISSN: 19290748 NLM ISO Abbreviation: JMIR Res Protoc Subsets: PubMed not MEDLINE
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  Data: Lessening Organ Dysfunction With Vitamin C (LOVIT) Trial: Statistical Analysis Plan.
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Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Annane+D%22">Annane D</searchLink>; Department of Intensive Care Medicine, Raymond-Poincaré Hospital (Assistance Publique - Hôpitaux de Paris [AP-HP]), Garches, France.; Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay Campus Université de Versailles Saint-Quentin-en-Yvelines, Versailles, France.; Fédération Hospitalo-Universitaire SEPSIS, Garches, France.<br /><searchLink fieldCode="AU" term="%22Arabi+YM%22">Arabi YM</searchLink>; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; Department of Intensive Care, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Battista+MC%22">Battista MC</searchLink>; Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Cohen+D%22">Cohen D</searchLink>; Bishop's University, Sherbroooke, QC, Canada.; Massawippi Valley Foundation, Ayer's Cliff, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Cook+DJ%22">Cook DJ</searchLink>; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Department of Critical Care, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Guyatt+GH%22">Guyatt GH</searchLink>; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Heyland+DK%22">Heyland DK</searchLink>; Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada.; Kingston General Health Research Institute, Kingston Health Sciences Centre, Kingston, ON, Canada.; Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Kanji+S%22">Kanji S</searchLink>; 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Department of Medicine, Université Laval, Québec, QC, Canada.; Department of Anesthesiology and Critical Care, Université Laval, Québec, QC, Canada.; Population Health and Optimal Health Practices Research Unit, Traumatology - Emergency - Critical Care Medicine, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Centre Hospitalier Universitaire de Québec - Université Laval, Québec, QC, Canada.; Critical Care Medicine Service, Centre Hospitalier Universitaire de Québec - Université Laval, Quebec, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Leblanc+R%22">Leblanc R</searchLink>; Department of Medicine, Centre Hospitalier Universitaire Dr Georges-L. 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