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GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity.

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Title: GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity.
Authors: Cox MJ; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Bioinformatics and Computational Biology, University of Minnesota Graduate School, Minneapolis, MN, USA., Manriquez Roman C; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA., Tapper EE; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Siegler EL; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Chappell D; Humanigen, Inc, Burlingame, CA, USA., Durrant C; Humanigen, Inc, Burlingame, CA, USA., Ahmed O; Humanigen, Inc, Burlingame, CA, USA., Sinha S; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Mwangi R; Bioinformatics and Computational Biology, University of Minnesota Graduate School, Minneapolis, MN, USA.; Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA., Scott NS; Bioinformatics and Computational Biology, University of Minnesota Graduate School, Minneapolis, MN, USA.; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA., Hefazi M; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Schick KJ; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA.; Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Horvei P; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Department of Pediatric Hematology/Oncology, Mayo Clinic, Rochester, MN, USA., Ruff MW; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Can I; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Adada M; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Bezerra E; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Kankeu Fonkoua LA; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Parikh SA; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Kay NE; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Sakemura R; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Kenderian SS; T Cell Engineering, Mayo Clinic, Rochester, MN, USA. kenderian.saad@mayo.edu.; Division of Hematology, Mayo Clinic, Rochester, MN, USA. kenderian.saad@mayo.edu.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA. kenderian.saad@mayo.edu.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA. kenderian.saad@mayo.edu.; Department of Immunology, Mayo Clinic, Rochester, MN, USA. kenderian.saad@mayo.edu.
Source: Leukemia [Leukemia] 2022 Jun; Vol. 36 (6), pp. 1635-1645. Date of Electronic Publication: 2022 Apr 19.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity.
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  Data: <searchLink fieldCode="AU" term="%22Cox+MJ%22">Cox MJ</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Bioinformatics and Computational Biology, University of Minnesota Graduate School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Manriquez+Roman+C%22">Manriquez Roman C</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Tapper+EE%22">Tapper EE</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Siegler+EL%22">Siegler EL</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Chappell+D%22">Chappell D</searchLink>; Humanigen, Inc, Burlingame, CA, USA.<br /><searchLink fieldCode="AU" term="%22Durrant+C%22">Durrant C</searchLink>; Humanigen, Inc, Burlingame, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ahmed+O%22">Ahmed O</searchLink>; Humanigen, Inc, Burlingame, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sinha+S%22">Sinha S</searchLink>; Division of Hematology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Mwangi+R%22">Mwangi R</searchLink>; Bioinformatics and Computational Biology, University of Minnesota Graduate School, Minneapolis, MN, USA.; Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Scott+NS%22">Scott NS</searchLink>; Bioinformatics and Computational Biology, University of Minnesota Graduate School, Minneapolis, MN, USA.; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hefazi+M%22">Hefazi M</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Schick+KJ%22">Schick KJ</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA.; Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Horvei+P%22">Horvei P</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Department of Pediatric Hematology/Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Ruff+MW%22">Ruff MW</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Department of Neurology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Can+I%22">Can I</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Adada+M%22">Adada M</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Bezerra+E%22">Bezerra E</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Kankeu+Fonkoua+LA%22">Kankeu Fonkoua LA</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Parikh+SA%22">Parikh SA</searchLink>; Division of Hematology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Kay+NE%22">Kay NE</searchLink>; Division of Hematology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Sakemura+R%22">Sakemura R</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Kenderian+SS%22">Kenderian SS</searchLink>; T Cell Engineering, Mayo Clinic, Rochester, MN, USA. kenderian.saad@mayo.edu.; Division of Hematology, Mayo Clinic, Rochester, MN, USA. kenderian.saad@mayo.edu.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA. kenderian.saad@mayo.edu.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA. kenderian.saad@mayo.edu.; Department of Immunology, Mayo Clinic, Rochester, MN, USA. kenderian.saad@mayo.edu.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2022 Jun; Vol. 36 (6), pp. 1635-1645. <i>Date of Electronic Publication: </i>2022 Apr 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%2C+Specialist+Journals%22">Nature Publishing Group, Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8704895 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5551 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208876924%22">08876924 </searchLink><i>NLM ISO Abbreviation: </i>Leukemia <i>Subsets: </i>MEDLINE
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