GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity.
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| Title: | GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity. |
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| Authors: | Cox MJ; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Bioinformatics and Computational Biology, University of Minnesota Graduate School, Minneapolis, MN, USA., Manriquez Roman C; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA., Tapper EE; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Siegler EL; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Chappell D; Humanigen, Inc, Burlingame, CA, USA., Durrant C; Humanigen, Inc, Burlingame, CA, USA., Ahmed O; Humanigen, Inc, Burlingame, CA, USA., Sinha S; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Mwangi R; Bioinformatics and Computational Biology, University of Minnesota Graduate School, Minneapolis, MN, USA.; Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA., Scott NS; Bioinformatics and Computational Biology, University of Minnesota Graduate School, Minneapolis, MN, USA.; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA., Hefazi M; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Schick KJ; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA.; Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA., Horvei P; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Department of Pediatric Hematology/Oncology, Mayo Clinic, Rochester, MN, USA., Ruff MW; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Can I; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA., Adada M; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Bezerra E; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Kankeu Fonkoua LA; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA.; Department of Oncology, Mayo Clinic, Rochester, MN, USA., Parikh SA; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Kay NE; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Sakemura R; T Cell Engineering, Mayo Clinic, Rochester, MN, USA.; Division of Hematology, Mayo Clinic, Rochester, MN, USA., Kenderian SS; T Cell Engineering, Mayo Clinic, Rochester, MN, USA. kenderian.saad@mayo.edu.; Division of Hematology, Mayo Clinic, Rochester, MN, USA. kenderian.saad@mayo.edu.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA. kenderian.saad@mayo.edu.; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA. kenderian.saad@mayo.edu.; Department of Immunology, Mayo Clinic, Rochester, MN, USA. kenderian.saad@mayo.edu. |
| Source: | Leukemia [Leukemia] 2022 Jun; Vol. 36 (6), pp. 1635-1645. Date of Electronic Publication: 2022 Apr 19. |
| Publication Type: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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