Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.
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| Title: | Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms. |
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| Authors: | Stevens LJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Pruijssers AJ; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, TN 37232, USA., Lee HW; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada., Gordon CJ; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada., Tchesnokov EP; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada., Gribble J; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., George AS; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Hughes TM; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Lu X; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Li J; Gilead Sciences Inc., Foster City, CA 94404, USA., Perry JK; Gilead Sciences Inc., Foster City, CA 94404, USA., Porter DP; Gilead Sciences Inc., Foster City, CA 94404, USA., Cihlar T; Gilead Sciences Inc., Foster City, CA 94404, USA., Sheahan TP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Götte M; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton AB T6G 2T9, Canada., Denison MR; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, TN 37232, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2022 Aug 03; Vol. 14 (656), pp. eabo0718. Date of Electronic Publication: 2022 Aug 03. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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