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Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication.

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Title: Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication.
Authors: Stegmann KM; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Justus von Liebig Weg 11, 37077 Göttingen, Germany., Dickmanns A; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Justus von Liebig Weg 11, 37077 Göttingen, Germany., Heinen N; Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Blaurock C; Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany., Karrasch T; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Justus von Liebig Weg 11, 37077 Göttingen, Germany., Breithaupt A; Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany., Klopfleisch R; Institute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany., Uhlig N; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany., Eberlein V; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany., Issmail L; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany., Herrmann ST; Department of Molecular Biochemistry, Ruhr University Bochum, Bochum, Germany., Schreieck A; Immunic AG, Gräfelfing, Germany., Peelen E; Immunic AG, Gräfelfing, Germany., Kohlhof H; Immunic AG, Gräfelfing, Germany., Sadeghi B; Friedrich-Loeffler-Institut, Institute of Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, Germany., Riek A; Friedrich-Loeffler-Institut, Institute of Animal Welfare and Animal Husbandry, Celle, Germany., Speakman JR; Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK., Groß U; Institute of Medical Microbiology and Virology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen, Germany., Görlich D; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany., Vitt D; Immunic AG, Gräfelfing, Germany., Müller T; Department of Molecular Biochemistry, Ruhr University Bochum, Bochum, Germany.; Institute of Psychiatric Phenomics and Genomics (IPPG), Organoid Laboratory, University Hospital, LMU Munich, Munich, Germany., Grunwald T; Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany., Pfaender S; Department of Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany., Balkema-Buschmann A; Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany., Dobbelstein M; Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Justus von Liebig Weg 11, 37077 Göttingen, Germany.
Source: IScience [iScience] 2022 May 20; Vol. 25 (5), pp. 104293. Date of Electronic Publication: 2022 Apr 25.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication.
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