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Patient-derived micro-organospheres enable clinical precision oncology.

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Title: Patient-derived micro-organospheres enable clinical precision oncology.
Authors: Ding S; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA; Xilis, Inc., Durham, NC 27713, USA., Hsu C; College of Arts and Sciences, University of Chapel Hill, Chapel Hill, NC 27599, USA., Wang Z; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA; Xilis, Inc., Durham, NC 27713, USA., Natesh NR; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Millen R; Oncode, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center (UMC) Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands., Negrete M; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Giroux N; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Rivera GO; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Dohlman A; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Bose S; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Rotstein T; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Spiller K; Xilis, Inc., Durham, NC 27713, USA., Yeung A; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Sun Z; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Jiang C; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA., Xi R; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Wilkin B; Xilis, Inc., Durham, NC 27713, USA., Randon PM; National Institute of Environmental Health Sciences (NIEHS), Durham, NC 27709, USA., Williamson I; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA., Nelson DA; Xilis, Inc., Durham, NC 27713, USA., Delubac D; Xilis, Inc., Durham, NC 27713, USA., Oh S; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA., Rupprecht G; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA., Isaacs J; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA., Jia J; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA., Chen C; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA., Shen JP; Department of Gastrointestinal Medical Oncology, MD Anderson, Houston, TX 77030, USA., Kopetz S; Department of Gastrointestinal Medical Oncology, MD Anderson, Houston, TX 77030, USA., McCall S; Department of Pathology, Duke University, Durham, NC 27708, USA., Smith A; Xilis, Inc., Durham, NC 27713, USA., Gjorevski N; Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel 4058, Switzerland., Walz AC; Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel 4058, Switzerland., Antonia S; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA., Marrer-Berger E; Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel 4058, Switzerland., Clevers H; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Oncode, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center (UMC) Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel 4058, Switzerland. Electronic address: h.clevers@hubrecht.eu., Hsu D; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA. Electronic address: shiaowen.hsu@duke.edu., Shen X; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA. Electronic address: xiling.shen@terasaki.org.
Source: Cell stem cell [Cell Stem Cell] 2022 Jun 02; Vol. 29 (6), pp. 905-917.e6. Date of Electronic Publication: 2022 May 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Patient-derived micro-organospheres enable clinical precision oncology.
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  Data: <searchLink fieldCode="AU" term="%22Ding+S%22">Ding S</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA; Xilis, Inc., Durham, NC 27713, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+C%22">Hsu C</searchLink>; College of Arts and Sciences, University of Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA; Xilis, Inc., Durham, NC 27713, USA.<br /><searchLink fieldCode="AU" term="%22Natesh+NR%22">Natesh NR</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Millen+R%22">Millen R</searchLink>; Oncode, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center (UMC) Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Negrete+M%22">Negrete M</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Giroux+N%22">Giroux N</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Rivera+GO%22">Rivera GO</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Dohlman+A%22">Dohlman A</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Bose+S%22">Bose S</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Rotstein+T%22">Rotstein T</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Spiller+K%22">Spiller K</searchLink>; Xilis, Inc., Durham, NC 27713, USA.<br /><searchLink fieldCode="AU" term="%22Yeung+A%22">Yeung A</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Sun+Z%22">Sun Z</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+C%22">Jiang C</searchLink>; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Xi+R%22">Xi R</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Wilkin+B%22">Wilkin B</searchLink>; Xilis, Inc., Durham, NC 27713, USA.<br /><searchLink fieldCode="AU" term="%22Randon+PM%22">Randon PM</searchLink>; National Institute of Environmental Health Sciences (NIEHS), Durham, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Williamson+I%22">Williamson I</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Nelson+DA%22">Nelson DA</searchLink>; Xilis, Inc., Durham, NC 27713, USA.<br /><searchLink fieldCode="AU" term="%22Delubac+D%22">Delubac D</searchLink>; Xilis, Inc., Durham, NC 27713, USA.<br /><searchLink fieldCode="AU" term="%22Oh+S%22">Oh S</searchLink>; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Rupprecht+G%22">Rupprecht G</searchLink>; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Isaacs+J%22">Isaacs J</searchLink>; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Jia+J%22">Jia J</searchLink>; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Shen+JP%22">Shen JP</searchLink>; Department of Gastrointestinal Medical Oncology, MD Anderson, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Kopetz+S%22">Kopetz S</searchLink>; Department of Gastrointestinal Medical Oncology, MD Anderson, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22McCall+S%22">McCall S</searchLink>; Department of Pathology, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Smith+A%22">Smith A</searchLink>; Xilis, Inc., Durham, NC 27713, USA.<br /><searchLink fieldCode="AU" term="%22Gjorevski+N%22">Gjorevski N</searchLink>; Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel 4058, Switzerland.<br /><searchLink fieldCode="AU" term="%22Walz+AC%22">Walz AC</searchLink>; Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel 4058, Switzerland.<br /><searchLink fieldCode="AU" term="%22Antonia+S%22">Antonia S</searchLink>; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Marrer-Berger+E%22">Marrer-Berger E</searchLink>; Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel 4058, Switzerland.<br /><searchLink fieldCode="AU" term="%22Clevers+H%22">Clevers H</searchLink>; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Oncode, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center (UMC) Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Roche Pharmaceutical Research and Early Development, Roche Innovation Center, Basel 4058, Switzerland. Electronic address: h.clevers@hubrecht.eu.<br /><searchLink fieldCode="AU" term="%22Hsu+D%22">Hsu D</searchLink>; Division of Medical Oncology, Duke Cancer Institute, Duke University, Durham, NC 27708, USA. Electronic address: shiaowen.hsu@duke.edu.<br /><searchLink fieldCode="AU" term="%22Shen+X%22">Shen X</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC 27708, USA; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA. Electronic address: xiling.shen@terasaki.org.
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  Data: <searchLink fieldCode="JN" term="%22101311472%22">Cell stem cell</searchLink> [Cell Stem Cell] 2022 Jun 02; Vol. 29 (6), pp. 905-917.e6. <i>Date of Electronic Publication: </i>2022 May 03.
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