Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action.
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| Title: | Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action. |
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| Authors: | Milicaj J; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA., Hassan BA; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA., Cote JM; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA., Ramirez-Mondragon CA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, 55455, USA., Jaunbocus N; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA., Rafalowski A; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA., Patel KR; Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA., Castro CD; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA., Muthyala R; Department of Experimental and Clinical Pharmacology, College Pharmacy, University of Minnesota, Minneapolis, MN, 55455, USA., Sham YY; Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA. shamx002@umn.edu.; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, 55455, USA. shamx002@umn.edu., Taylor EA; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA. eataylor@wesleyan.edu. |
| Source: | Scientific reports [Sci Rep] 2022 May 04; Vol. 12 (1), pp. 7302. Date of Electronic Publication: 2022 May 04. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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