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Serum Concentrations of Losartan Metabolites Correlate With Improved Physical Function in a Pilot Study of Prefrail Older Adults.

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Title: Serum Concentrations of Losartan Metabolites Correlate With Improved Physical Function in a Pilot Study of Prefrail Older Adults.
Authors: Lee JL; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.; Department of Internal Medicine, Division of Geriatric and Palliative Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Zhang C; Department of Oncology, Division of Cancer Chemical and Structural Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Westbrook R; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA., Gabrawy MM; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA., Nidadavolu L; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA., Yang H; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA., Marx R; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA., Wu Y; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA., Anders NM; Department of Oncology, Division of Cancer Chemical and Structural Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; The Johns Hopkins Analytical Pharmacology Core Laboratory, Clinical Pharmacology, Baltimore, MD, USA., Ma L; Department of Geriatrics, Xuanwu Hospital, Capital Medical University, China National Clinical Research Center for Geriatric Disorders, Beijing, China., Bichara MD; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA., Kwak MJ; Department of Internal Medicine, Division of Geriatric and Palliative Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Buta B; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA., Khadeer M; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA., Yenokyan G; Johns Hopkins Biostatistics Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Tian J; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA., Xue QL; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA., Siragy HM; Department of Medicine, Division of Endocrine and Metabolism, University of Virginia, Charlottesville, Virginia, USA., Carey RM; Department of Medicine, Division of Endocrine and Metabolism, University of Virginia, Charlottesville, Virginia, USA., de Cabo R; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA., Moaddel R; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA., Rudek MA; The Johns Hopkins Analytical Pharmacology Core Laboratory, Clinical Pharmacology, Baltimore, MD, USA.; Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA., Le A; The Johns Hopkins Analytical Pharmacology Core Laboratory, Clinical Pharmacology, Baltimore, MD, USA.; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Walston JD; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA., Abadir PM; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.
Source: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2022 Dec 29; Vol. 77 (12), pp. 2356-2366.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837 Publication Model: Print Cited Medium: Internet ISSN: 1758-535X (Electronic) Linking ISSN: 10795006 NLM ISO Abbreviation: J Gerontol A Biol Sci Med Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Serum Concentrations of Losartan Metabolites Correlate With Improved Physical Function in a Pilot Study of Prefrail Older Adults.
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  Data: <searchLink fieldCode="AU" term="%22Lee+JL%22">Lee JL</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.; Department of Internal Medicine, Division of Geriatric and Palliative Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Department of Oncology, Division of Cancer Chemical and Structural Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Westbrook+R%22">Westbrook R</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Gabrawy+MM%22">Gabrawy MM</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Nidadavolu+L%22">Nidadavolu L</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Marx+R%22">Marx R</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Anders+NM%22">Anders NM</searchLink>; Department of Oncology, Division of Cancer Chemical and Structural Biology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; The Johns Hopkins Analytical Pharmacology Core Laboratory, Clinical Pharmacology, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ma+L%22">Ma L</searchLink>; Department of Geriatrics, Xuanwu Hospital, Capital Medical University, China National Clinical Research Center for Geriatric Disorders, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Bichara+MD%22">Bichara MD</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Kwak+MJ%22">Kwak MJ</searchLink>; Department of Internal Medicine, Division of Geriatric and Palliative Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Buta+B%22">Buta B</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Khadeer+M%22">Khadeer M</searchLink>; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Yenokyan+G%22">Yenokyan G</searchLink>; Johns Hopkins Biostatistics Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Tian+J%22">Tian J</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Xue+QL%22">Xue QL</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Siragy+HM%22">Siragy HM</searchLink>; Department of Medicine, Division of Endocrine and Metabolism, University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Carey+RM%22">Carey RM</searchLink>; Department of Medicine, Division of Endocrine and Metabolism, University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22de+Cabo+R%22">de Cabo R</searchLink>; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Ferrucci+L%22">Ferrucci L</searchLink>; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Moaddel+R%22">Moaddel R</searchLink>; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Rudek+MA%22">Rudek MA</searchLink>; The Johns Hopkins Analytical Pharmacology Core Laboratory, Clinical Pharmacology, Baltimore, MD, USA.; Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Le+A%22">Le A</searchLink>; The Johns Hopkins Analytical Pharmacology Core Laboratory, Clinical Pharmacology, Baltimore, MD, USA.; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Walston+JD%22">Walston JD</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Abadir+PM%22">Abadir PM</searchLink>; Department of Medicine, Division of Geriatric Medicine and Gerontology, The Johns Hopkins University School of Medicine , Baltimore, Maryland, USA.
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