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Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia.

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Title: Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia.
Authors: Laukkanen S; Tampere Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Veloso A; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Yan C; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Oksa L; Tampere Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Alpert EJ; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Do D; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Hyvärinen N; Tampere Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., McCarthy K; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Adhikari A; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Yang Q; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Iyer S; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Garcia SP; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Pello A; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland., Ruokoranta T; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland., Moisio S; The Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland., Adhikari S; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland., Yoder JA; Department of Molecular Biomedical Sciences, Comparative Medicine Institute, and Center for Human Health and the Environment, North Carolina State University, Raleigh, NC., Gallagher K; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA., Whelton L; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Allen JR; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Jin AH; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA., Loontiens S; Cancer Research Institute Ghent and Center for Medical Genetics, Ghent, Belgium., Heinäniemi M; The Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland., Kelliher M; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA., Heckman CA; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland., Lohi O; Tampere Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Tampere University Hospital, Tays Cancer Center, Tampere, Finland., Langenau DM; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.
Source: Blood [Blood] 2022 Oct 27; Vol. 140 (17), pp. 1891-1906.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Laukkanen+S%22">Laukkanen S</searchLink>; Tampere Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Veloso+A%22">Veloso A</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Yan+C%22">Yan C</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Oksa+L%22">Oksa L</searchLink>; Tampere Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Alpert+EJ%22">Alpert EJ</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Do+D%22">Do D</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Hyvärinen+N%22">Hyvärinen N</searchLink>; Tampere Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22McCarthy+K%22">McCarthy K</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Adhikari+A%22">Adhikari A</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Yang+Q%22">Yang Q</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Iyer+S%22">Iyer S</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Garcia+SP%22">Garcia SP</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Pello+A%22">Pello A</searchLink>; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Ruokoranta+T%22">Ruokoranta T</searchLink>; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Moisio+S%22">Moisio S</searchLink>; The Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Adhikari+S%22">Adhikari S</searchLink>; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Yoder+JA%22">Yoder JA</searchLink>; Department of Molecular Biomedical Sciences, Comparative Medicine Institute, and Center for Human Health and the Environment, North Carolina State University, Raleigh, NC.<br /><searchLink fieldCode="AU" term="%22Gallagher+K%22">Gallagher K</searchLink>; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA.<br /><searchLink fieldCode="AU" term="%22Whelton+L%22">Whelton L</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Allen+JR%22">Allen JR</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Jin+AH%22">Jin AH</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Loontiens+S%22">Loontiens S</searchLink>; Cancer Research Institute Ghent and Center for Medical Genetics, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Heinäniemi+M%22">Heinäniemi M</searchLink>; The Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Kelliher+M%22">Kelliher M</searchLink>; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA.<br /><searchLink fieldCode="AU" term="%22Heckman+CA%22">Heckman CA</searchLink>; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Lohi+O%22">Lohi O</searchLink>; Tampere Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Tampere University Hospital, Tays Cancer Center, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Langenau+DM%22">Langenau DM</searchLink>; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA.; Harvard Stem Cell Institute, Boston, MA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.
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