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Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective.

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Title: Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective.
Authors: Chu X; Department of ADME and Discovery Toxicology, Merck & Co., Inc., Kenilworth, New Jersey, USA., Prasad B; Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA., Neuhoff S; Certara UK Ltd., Sheffield, UK., Yoshida K; Clinical Pharmacology, Genentech Research and Early Development, South San Francisco, California, USA., Leeder JS; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri, USA., Mukherjee D; Clinical Pharmacology & Pharmacometrics, Research & Development, AbbVie, Inc., North Chicago, Illinois, USA., Taskar K; DMPK, IVIVT, GlaxoSmithKline R&D, Stevenage, UK., Varma MVS; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide R&D, Pfizer Inc, Groton, Connecticut, USA., Zhang X; Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Yang X; Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA., Galetin A; Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, Manchester, UK.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Sep; Vol. 112 (3), pp. 501-526. Date of Electronic Publication: 2022 Jun 21.
Publication Type: Journal Article; Review
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective.
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  Data: <searchLink fieldCode="AU" term="%22Chu+X%22">Chu X</searchLink>; Department of ADME and Discovery Toxicology, Merck & Co., Inc., Kenilworth, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Prasad+B%22">Prasad B</searchLink>; Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Neuhoff+S%22">Neuhoff S</searchLink>; Certara UK Ltd., Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Yoshida+K%22">Yoshida K</searchLink>; Clinical Pharmacology, Genentech Research and Early Development, South San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Leeder+JS%22">Leeder JS</searchLink>; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Mukherjee+D%22">Mukherjee D</searchLink>; Clinical Pharmacology & Pharmacometrics, Research & Development, AbbVie, Inc., North Chicago, Illinois, USA.<br /><searchLink fieldCode="AU" term="%22Taskar+K%22">Taskar K</searchLink>; DMPK, IVIVT, GlaxoSmithKline R&D, Stevenage, UK.<br /><searchLink fieldCode="AU" term="%22Varma+MVS%22">Varma MVS</searchLink>; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Worldwide R&D, Pfizer Inc, Groton, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Galetin+A%22">Galetin A</searchLink>; Centre for Applied Pharmacokinetic Research, School of Health Sciences, The University of Manchester, Manchester, UK.
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              Text: 2022 Sep
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