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First-in-man, first-in-class phase I study with the monopolar spindle 1 kinase inhibitor S81694 administered intravenously in adult patients with advanced, metastatic solid tumours.

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Title: First-in-man, first-in-class phase I study with the monopolar spindle 1 kinase inhibitor S81694 administered intravenously in adult patients with advanced, metastatic solid tumours.
Authors: Schöffski P; Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium. Electronic address: patrick.schoffski@uzleuven.be., Awada A; Clinical Trials Conduct Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., de la Bigne AM; TA Oncology, Institut de Recherches Internationales Servier, Suresnes, France., Felloussi Z; TA Oncology, Institut de Recherches Internationales Servier, Suresnes, France., Burbridge M; TA Oncology, Institut de Recherches Internationales Servier, Suresnes, France., Cantero F; TA Oncology, Institut de Recherches Internationales Servier, Suresnes, France., Colombo R; Nerviano Medical Sciences S.r.l., Nerviano, Milan, Italy., Maruzzelli S; Nerviano Medical Sciences S.r.l., Nerviano, Milan, Italy., Ammattatelli K; Nerviano Medical Sciences S.r.l., Nerviano, Milan, Italy., de Jonge M; Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Aftimos P; Clinical Trials Conduct Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium., Dumez H; Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium., Sleijfer S; Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2022 Jul; Vol. 169, pp. 135-145. Date of Electronic Publication: 2022 May 11.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: First-in-man, first-in-class phase I study with the monopolar spindle 1 kinase inhibitor S81694 administered intravenously in adult patients with advanced, metastatic solid tumours.
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  Data: <searchLink fieldCode="AU" term="%22Schöffski+P%22">Schöffski P</searchLink>; Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium. Electronic address: patrick.schoffski@uzleuven.be.<br /><searchLink fieldCode="AU" term="%22Awada+A%22">Awada A</searchLink>; Clinical Trials Conduct Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22de+la+Bigne+AM%22">de la Bigne AM</searchLink>; TA Oncology, Institut de Recherches Internationales Servier, Suresnes, France.<br /><searchLink fieldCode="AU" term="%22Felloussi+Z%22">Felloussi Z</searchLink>; TA Oncology, Institut de Recherches Internationales Servier, Suresnes, France.<br /><searchLink fieldCode="AU" term="%22Burbridge+M%22">Burbridge M</searchLink>; TA Oncology, Institut de Recherches Internationales Servier, Suresnes, France.<br /><searchLink fieldCode="AU" term="%22Cantero+F%22">Cantero F</searchLink>; TA Oncology, Institut de Recherches Internationales Servier, Suresnes, France.<br /><searchLink fieldCode="AU" term="%22Colombo+R%22">Colombo R</searchLink>; Nerviano Medical Sciences S.r.l., Nerviano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Maruzzelli+S%22">Maruzzelli S</searchLink>; Nerviano Medical Sciences S.r.l., Nerviano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ammattatelli+K%22">Ammattatelli K</searchLink>; Nerviano Medical Sciences S.r.l., Nerviano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22de+Jonge+M%22">de Jonge M</searchLink>; Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Aftimos+P%22">Aftimos P</searchLink>; Clinical Trials Conduct Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Dumez+H%22">Dumez H</searchLink>; Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Sleijfer+S%22">Sleijfer S</searchLink>; Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2022 Jul; Vol. 169, pp. 135-145. <i>Date of Electronic Publication: </i>2022 May 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9005373 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0852 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209598049%22">09598049 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Cancer <i>Subsets: </i>MEDLINE
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