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Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.

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Title: Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.
Authors: Spaan AN; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands., Neehus AL; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.; Institute of Experimental Hematology, REBIRTH Research Center for Translational and Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany., Laplantine E; Centre d'Immunologie et des Maladies Infectieuses, INSERM U1135, CNRS ERL8255, Sorbonne University, 75724 Paris, France.; Institut de Recherche St. Louis, Hôpital St. Louis, INSERM U944, CNRS U7212, Paris Cité University, 75010 Paris, France., Staels F; Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium., Ogishi M; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA., Seeleuthner Y; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France., Rapaport F; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA., Lacey KA; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., Van Nieuwenhove E; Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.; Department of Pediatric Rheumatology and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands., Chrabieh M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France., Hum D; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA., Migaud M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France., Izmiryan A; Imagine Institute, Paris Cité University, 75015 Paris, France.; Laboratory of Genetic Skin Diseases, INSERM U1163, 75015 Paris, France., Lorenzo L; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France., Kochetkov T; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA., Heesterbeek DAC; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands., Bardoel BW; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands., DuMont AL; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., Dobbs K; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD 20852, USA., Chardonnet S; Plateforme Post-génomique de la Pitié-Salpêtrière, P3S, UMS Production et Analyse de données en Sciences de la vie et en Santé, PASS, INSERM, Sorbonne University, 75013 Paris, France., Heissel S; Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA., Baslan T; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Zhang P; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA., Yang R; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA., Bogunovic D; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Wunderink HF; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands., Haas PA; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands., Molina H; Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA., Van Buggenhout G; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.; Center for Human Genetics, University Hospitals Leuven, 3000 Leuven, Belgium., Lyonnet S; Imagine Institute, Paris Cité University, 75015 Paris, France.; Laboratory Embryology and Genetics of Malformations, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France., Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD 20852, USA., Seppänen MRJ; Rare Disease and Pediatric Research Centers, Children and Adolescents, University of Helsinki and HUS Helsinki University Hospital, 00260 Helsinki, Finland., Weil R; Centre d'Immunologie et des Maladies Infectieuses, INSERM U1135, CNRS ERL8255, Sorbonne University, 75724 Paris, France., Seminario G; Center for Clinical Immunology, Immunology Group Children's Hospital Ricardo Gutiérrez, C1425EFD Buenos Aires, Argentina., Gomez-Tello H; Immunology Department, Poblano Children's Hospital, 72190 Puebla, Mexico., Wouters C; Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.; Department of Pediatrics, University Hospitals Leuven, 3000 Leuven, Belgium., Mesdaghi M; Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, 15468-155514 Tehran, Iran., Shahrooei M; Clinical and Diagnostic Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.; Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, 15468-155514 Ahvaz, Iran., Bossuyt X; Clinical and Diagnostic Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium., Sag E; Department of Pediatric Rheumatology, Hacettepe University, 06230 Ankara, Turkey., Topaloglu R; Department of Pediatric Nephrology, Hacettepe University School of Medicine, Hacettepe University, 06230 Ankara, Turkey., Ozen S; Department of Pediatric Rheumatology, Hacettepe University, 06230 Ankara, Turkey., Leavis HL; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands., van Eijk MMJ; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands., Bezrodnik L; Center for Clinical Immunology, Immunology Group Children's Hospital Ricardo Gutiérrez, C1425EFD Buenos Aires, Argentina., Blancas Galicia L; Immune Deficiencies Laboratory National Institute of Pediatrics, 04530 Mexico City, Mexico., Hovnanian A; Imagine Institute, Paris Cité University, 75015 Paris, France.; Laboratory of Genetic Skin Diseases, INSERM U1163, 75015 Paris, France.; Department of Genetics, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France., Nassif A; Centre Médical, Institut Pasteur, 75724 Paris, France., Bader-Meunier B; Imagine Institute, Paris Cité University, 75015 Paris, France.; Pediatric Immunology, Hematology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.; Laboratory of Immunogenetics of Pediatric Autoimmunity, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France., Neven B; Imagine Institute, Paris Cité University, 75015 Paris, France.; Pediatric Immunology, Hematology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.; Laboratory of Immunogenetics of Pediatric Autoimmunity, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France., Meyts I; Laboratory of Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.; Department of Pediatrics, Jeffrey Modell Diagnostic and Research Network Center, University Hospitals Leuven, 3000 Leuven, Belgium., Schrijvers R; Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium., Puel A; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France., Bustamante J; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.; Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France., Aksentijevich I; Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD 20892, USA., Kastner DL; Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD 20892, USA., Torres VJ; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA., Humblet-Baron S; Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium., Liston A; Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.; VIB Center for Brain and Disease Research, Leuven 3000, Belgium.; Immunology Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK., Abel L; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France., Boisson B; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France., Casanova JL; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.; Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Source: Science (New York, N.Y.) [Science] 2022 Jun 17; Vol. 376 (6599), pp. eabm6380. Date of Electronic Publication: 2022 Jun 17.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Spaan+AN%22">Spaan AN</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Neehus+AL%22">Neehus AL</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.; Institute of Experimental Hematology, REBIRTH Research Center for Translational and Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Laplantine+E%22">Laplantine E</searchLink>; Centre d'Immunologie et des Maladies Infectieuses, INSERM U1135, CNRS ERL8255, Sorbonne University, 75724 Paris, France.; Institut de Recherche St. Louis, Hôpital St. Louis, INSERM U944, CNRS U7212, Paris Cité University, 75010 Paris, France.<br /><searchLink fieldCode="AU" term="%22Staels+F%22">Staels F</searchLink>; Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Ogishi+M%22">Ogishi M</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Seeleuthner+Y%22">Seeleuthner Y</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Rapaport+F%22">Rapaport F</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Lacey+KA%22">Lacey KA</searchLink>; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Van+Nieuwenhove+E%22">Van Nieuwenhove E</searchLink>; Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.; Department of Pediatric Rheumatology and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Chrabieh+M%22">Chrabieh M</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Hum+D%22">Hum D</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Migaud+M%22">Migaud M</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Izmiryan+A%22">Izmiryan A</searchLink>; Imagine Institute, Paris Cité University, 75015 Paris, France.; Laboratory of Genetic Skin Diseases, INSERM U1163, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Lorenzo+L%22">Lorenzo L</searchLink>; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Kochetkov+T%22">Kochetkov T</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Heesterbeek+DAC%22">Heesterbeek DAC</searchLink>; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bardoel+BW%22">Bardoel BW</searchLink>; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22DuMont+AL%22">DuMont AL</searchLink>; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Dobbs+K%22">Dobbs K</searchLink>; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD 20852, USA.<br /><searchLink fieldCode="AU" term="%22Chardonnet+S%22">Chardonnet S</searchLink>; Plateforme Post-génomique de la Pitié-Salpêtrière, P3S, UMS Production et Analyse de données en Sciences de la vie et en Santé, PASS, INSERM, Sorbonne University, 75013 Paris, France.<br /><searchLink fieldCode="AU" term="%22Heissel+S%22">Heissel S</searchLink>; Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Baslan+T%22">Baslan T</searchLink>; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+P%22">Zhang P</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Bogunovic+D%22">Bogunovic D</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Wunderink+HF%22">Wunderink HF</searchLink>; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Haas+PA%22">Haas PA</searchLink>; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Molina+H%22">Molina H</searchLink>; Proteomics Resource Center, The Rockefeller University, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Van+Buggenhout+G%22">Van Buggenhout G</searchLink>; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.; Center for Human Genetics, University Hospitals Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Lyonnet+S%22">Lyonnet S</searchLink>; Imagine Institute, Paris Cité University, 75015 Paris, France.; Laboratory Embryology and Genetics of Malformations, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Notarangelo+LD%22">Notarangelo LD</searchLink>; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD 20852, USA.<br /><searchLink fieldCode="AU" term="%22Seppänen+MRJ%22">Seppänen MRJ</searchLink>; Rare Disease and Pediatric Research Centers, Children and Adolescents, University of Helsinki and HUS Helsinki University Hospital, 00260 Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Weil+R%22">Weil R</searchLink>; Centre d'Immunologie et des Maladies Infectieuses, INSERM U1135, CNRS ERL8255, Sorbonne University, 75724 Paris, France.<br /><searchLink fieldCode="AU" term="%22Seminario+G%22">Seminario G</searchLink>; Center for Clinical Immunology, Immunology Group Children's Hospital Ricardo Gutiérrez, C1425EFD Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Gomez-Tello+H%22">Gomez-Tello H</searchLink>; Immunology Department, Poblano Children's Hospital, 72190 Puebla, Mexico.<br /><searchLink fieldCode="AU" term="%22Wouters+C%22">Wouters C</searchLink>; Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.; Department of Pediatrics, University Hospitals Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Mesdaghi+M%22">Mesdaghi M</searchLink>; Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, 15468-155514 Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Shahrooei+M%22">Shahrooei M</searchLink>; Clinical and Diagnostic Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.; Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, 15468-155514 Ahvaz, Iran.<br /><searchLink fieldCode="AU" term="%22Bossuyt+X%22">Bossuyt X</searchLink>; Clinical and Diagnostic Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Sag+E%22">Sag E</searchLink>; Department of Pediatric Rheumatology, Hacettepe University, 06230 Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Topaloglu+R%22">Topaloglu R</searchLink>; Department of Pediatric Nephrology, Hacettepe University School of Medicine, Hacettepe University, 06230 Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Ozen+S%22">Ozen S</searchLink>; Department of Pediatric Rheumatology, Hacettepe University, 06230 Ankara, Turkey.<br /><searchLink fieldCode="AU" term="%22Leavis+HL%22">Leavis HL</searchLink>; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Eijk+MMJ%22">van Eijk MMJ</searchLink>; Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bezrodnik+L%22">Bezrodnik L</searchLink>; Center for Clinical Immunology, Immunology Group Children's Hospital Ricardo Gutiérrez, C1425EFD Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Blancas+Galicia+L%22">Blancas Galicia L</searchLink>; Immune Deficiencies Laboratory National Institute of Pediatrics, 04530 Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Hovnanian+A%22">Hovnanian A</searchLink>; Imagine Institute, Paris Cité University, 75015 Paris, France.; Laboratory of Genetic Skin Diseases, INSERM U1163, 75015 Paris, France.; Department of Genetics, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Nassif+A%22">Nassif A</searchLink>; Centre Médical, Institut Pasteur, 75724 Paris, France.<br /><searchLink fieldCode="AU" term="%22Bader-Meunier+B%22">Bader-Meunier B</searchLink>; Imagine Institute, Paris Cité University, 75015 Paris, France.; Pediatric Immunology, Hematology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.; Laboratory of Immunogenetics of Pediatric Autoimmunity, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Neven+B%22">Neven B</searchLink>; Imagine Institute, Paris Cité University, 75015 Paris, France.; Pediatric Immunology, Hematology and Rheumatology Unit, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.; Laboratory of Immunogenetics of Pediatric Autoimmunity, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Meyts+I%22">Meyts I</searchLink>; Laboratory of Inborn Errors of Immunity, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.; Department of Pediatrics, Jeffrey Modell Diagnostic and Research Network Center, University Hospitals Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Schrijvers+R%22">Schrijvers R</searchLink>; Allergy and Clinical Immunology Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Puel+A%22">Puel A</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Bustamante+J%22">Bustamante J</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.; Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Aksentijevich+I%22">Aksentijevich I</searchLink>; Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Kastner+DL%22">Kastner DL</searchLink>; Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Torres+VJ%22">Torres VJ</searchLink>; Department of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Humblet-Baron+S%22">Humblet-Baron S</searchLink>; Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Liston+A%22">Liston A</searchLink>; Laboratory for Adaptive Immunology, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium.; VIB Center for Brain and Disease Research, Leuven 3000, Belgium.; Immunology Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK.<br /><searchLink fieldCode="AU" term="%22Abel+L%22">Abel L</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Boisson+B%22">Boisson B</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.<br /><searchLink fieldCode="AU" term="%22Casanova+JL%22">Casanova JL</searchLink>; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France.; Imagine Institute, Paris Cité University, 75015 Paris, France.; Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, 75015 Paris, France.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2022 Jun 17; Vol. 376 (6599), pp. eabm6380. <i>Date of Electronic Publication: </i>2022 Jun 17.
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  Data: Journal Article
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  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0404511 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-9203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200368075%22">00368075 </searchLink><i>NLM ISO Abbreviation: </i>Science <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=35587511
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      – Type: doi
        Value: 10.1126/science.abm6380
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      – Code: eng
        Text: English
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        StartPage: eabm6380
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      – TitleFull: Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.
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            – D: 17
              M: 06
              Text: 2022 Jun 17
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 1095-9203
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              Value: 376
            – Type: issue
              Value: 6599
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            – TitleFull: Science (New York, N.Y.)
              Type: main
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