View in EDS HTML Full Text PDF Full Text

A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.

Saved in:
Bibliographic Details
Title: A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.
Authors: Singh D; CN Bio Innovations Limited, Cambridge, United Kingdom., Deosarkar SP; Oncology Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts, United States of America., Cadogan E; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Flemington V; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Bray A; CN Bio Innovations Limited, Cambridge, United Kingdom., Zhang J; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts, United States of America., Reiserer RS; Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America., Schaffer DK; Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America., Gerken GB; Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America., Britt CM; Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America., Werner EM; Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America., Gibbons FD; DMPK, Oncology R&D, AstraZeneca, Boston, Massachusetts, United States of America., Kostrzewski T; CN Bio Innovations Limited, Cambridge, United Kingdom., Chambers CE; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Davies EJ; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Montoya AR; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Fok JHL; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom., Hughes D; CN Bio Innovations Limited, Cambridge, United Kingdom., Fabre K; MPS Center of Excellence, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts, United States of America., Wagoner MP; Oncology Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts, United States of America., Wikswo JP; Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America.; Departments of Biomedical Engineering and Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America., Scott CW; Oncology Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts, United States of America.
Source: PLoS biology [PLoS Biol] 2022 May 26; Vol. 20 (5), pp. e3001624. Date of Electronic Publication: 2022 May 26 (Print Publication: 2022).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 35617197
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Singh+D%22">Singh D</searchLink>; CN Bio Innovations Limited, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Deosarkar+SP%22">Deosarkar SP</searchLink>; Oncology Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Cadogan+E%22">Cadogan E</searchLink>; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Flemington+V%22">Flemington V</searchLink>; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bray+A%22">Bray A</searchLink>; CN Bio Innovations Limited, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Bioscience, Oncology R&D, AstraZeneca, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Reiserer+RS%22">Reiserer RS</searchLink>; Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Schaffer+DK%22">Schaffer DK</searchLink>; Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Gerken+GB%22">Gerken GB</searchLink>; Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Britt+CM%22">Britt CM</searchLink>; Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Werner+EM%22">Werner EM</searchLink>; Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Gibbons+FD%22">Gibbons FD</searchLink>; DMPK, Oncology R&D, AstraZeneca, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Kostrzewski+T%22">Kostrzewski T</searchLink>; CN Bio Innovations Limited, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chambers+CE%22">Chambers CE</searchLink>; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Davies+EJ%22">Davies EJ</searchLink>; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Montoya+AR%22">Montoya AR</searchLink>; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fok+JHL%22">Fok JHL</searchLink>; Bioscience, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hughes+D%22">Hughes D</searchLink>; CN Bio Innovations Limited, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fabre+K%22">Fabre K</searchLink>; MPS Center of Excellence, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Wagoner+MP%22">Wagoner MP</searchLink>; Oncology Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts, United States of America.<br /><searchLink fieldCode="AU" term="%22Wikswo+JP%22">Wikswo JP</searchLink>; Department of Physics and Astronomy and the Vanderbilt Institute for Integrative Biosystems Research and Education, Nashville, Tennessee, United States of America.; Departments of Biomedical Engineering and Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America.<br /><searchLink fieldCode="AU" term="%22Scott+CW%22">Scott CW</searchLink>; Oncology Safety, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, Massachusetts, United States of America.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101183755%22">PLoS biology</searchLink> [PLoS Biol] 2022 May 26; Vol. 20 (5), pp. e3001624. <i>Date of Electronic Publication: </i>2022 May 26 (<i>Print Publication: </i>2022).
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101183755 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1545-7885 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215449173%22">15449173 </searchLink><i>NLM ISO Abbreviation: </i>PLoS Biol <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=35617197
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1371/journal.pbio.3001624
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: e3001624
    Titles:
      – TitleFull: A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Singh D
      – PersonEntity:
          Name:
            NameFull: Deosarkar SP
      – PersonEntity:
          Name:
            NameFull: Cadogan E
      – PersonEntity:
          Name:
            NameFull: Flemington V
      – PersonEntity:
          Name:
            NameFull: Bray A
      – PersonEntity:
          Name:
            NameFull: Zhang J
      – PersonEntity:
          Name:
            NameFull: Reiserer RS
      – PersonEntity:
          Name:
            NameFull: Schaffer DK
      – PersonEntity:
          Name:
            NameFull: Gerken GB
      – PersonEntity:
          Name:
            NameFull: Britt CM
      – PersonEntity:
          Name:
            NameFull: Werner EM
      – PersonEntity:
          Name:
            NameFull: Gibbons FD
      – PersonEntity:
          Name:
            NameFull: Kostrzewski T
      – PersonEntity:
          Name:
            NameFull: Chambers CE
      – PersonEntity:
          Name:
            NameFull: Davies EJ
      – PersonEntity:
          Name:
            NameFull: Montoya AR
      – PersonEntity:
          Name:
            NameFull: Fok JHL
      – PersonEntity:
          Name:
            NameFull: Hughes D
      – PersonEntity:
          Name:
            NameFull: Fabre K
      – PersonEntity:
          Name:
            NameFull: Wagoner MP
      – PersonEntity:
          Name:
            NameFull: Wikswo JP
      – PersonEntity:
          Name:
            NameFull: Scott CW
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 26
              M: 05
              Text: 2022 May 26
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 1545-7885
          Numbering:
            – Type: volume
              Value: 20
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: PLoS biology
              Type: main
ResultId 1