A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models. - Singh D; Deosarkar SP; Cadogan E; Flemington V; Bray A; Zhang J; Reiserer RS; Schaffer DK; Gerken GB; Britt CM; Werner EM; Gibbons FD; et al. (PLoS biology, 2022)