Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation.
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| Title: | Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. |
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| Authors: | Yshii L; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium., Pasciuto E; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium., Bielefeld P; Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, Netherlands.; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Mascali L; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium., Lemaitre P; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium., Marino M; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium., Dooley J; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Kouser L; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Verschoren S; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium., Lagou V; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium., Kemps H; Cardio & Organ Systems (COST), Biomedical Research Institute (BIOMED), Hasselt University, Diepenbeek, Belgium., Gervois P; Cardio & Organ Systems (COST), Biomedical Research Institute (BIOMED), Hasselt University, Diepenbeek, Belgium., de Boer A; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium., Burton OT; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Wahis J; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium., Verhaert J; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium., Tareen SHK; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Roca CP; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Singh K; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Whyte CE; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Kerstens A; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium.; VIB Bio-Imaging Core, Leuven, Belgium., Callaerts-Vegh Z; KU Leuven, Faculty of Psychology, Laboratory of Biological Psychology, Leuven, Belgium., Poovathingal S; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium., Prezzemolo T; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium., Wierda K; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium.; VIB-KU Leuven Center for Brain & Disease Research, Electrophysiology Expertise Unit, Leuven, Belgium., Dashwood A; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Xie J; VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Faculty of Sciences, Ghent University, Ghent, Belgium., Van Wonterghem E; VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Faculty of Sciences, Ghent University, Ghent, Belgium., Creemers E; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium.; VIB-KU Leuven Center for Brain & Disease Research, Electrophysiology Expertise Unit, Leuven, Belgium., Aloulou M; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.; Toulouse Institute for Infectious and Inflammatory diseases (INFINITY), INSERM UMR1291, CNRS UMR 5051, Toulouse, France., Gsell W; KU Leuven, Department of Imaging and Pathology, Biomedical MRI, Leuven, Belgium., Abiega O; Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, Netherlands., Munck S; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium.; VIB Bio-Imaging Core, Leuven, Belgium., Vandenbroucke RE; VIB Center for Inflammation Research, Ghent, Belgium.; Department of Biomedical Molecular Biology, Faculty of Sciences, Ghent University, Ghent, Belgium., Bronckaers A; Cardio & Organ Systems (COST), Biomedical Research Institute (BIOMED), Hasselt University, Diepenbeek, Belgium., Lemmens R; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium.; University Hospitals Leuven, Department of Neurology, Leuven, Belgium., De Strooper B; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium.; Dementia Research Institute, University College London, London, United Kingdom., Van Den Bosch L; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium.; KU Leuven - Department of Neurosciences, Leuven, Belgium., Himmelreich U; KU Leuven, Department of Imaging and Pathology, Biomedical MRI, Leuven, Belgium., Fitzsimons CP; Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, Netherlands., Holt MG; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium. mholt@i3S.up.pt.; KU Leuven - Department of Neurosciences, Leuven, Belgium. mholt@i3S.up.pt.; Instituto de Investigaçāo e Inovaçāo em Saúde (i3S), University of Porto, Porto, Portugal. mholt@i3S.up.pt., Liston A; VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium. al989@cam.ac.uk.; KU Leuven, Department of Microbiology, Immunology and Transplantation, Leuven, Belgium. al989@cam.ac.uk.; Immunology Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom. al989@cam.ac.uk. |
| Source: | Nature immunology [Nat Immunol] 2022 Jun; Vol. 23 (6), pp. 878-891. Date of Electronic Publication: 2022 May 26. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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