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SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents.

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Title: SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents.
Authors: Garcia-Valtanen P; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia., Hope CM; Molecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia; Women's and Children's Health Network, North Adelaide, SA, Australia., Masavuli MG; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia., Yeow AEL; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia., Balachandran H; School of Medical Sciences, Faculty of Medicine, UNSW, Australia, Sydney, NSW, Australia., Mekonnen ZA; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia., Al-Delfi Z; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia., Abayasingam A; School of Medical Sciences, Faculty of Medicine, UNSW, Australia, Sydney, NSW, Australia., Agapiou D; School of Medical Sciences, Faculty of Medicine, UNSW, Australia, Sydney, NSW, Australia., Stella AO; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia., Aggarwal A; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia., Bouras G; Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia; The Department of Surgery - Otolaryngology, Head and Neck Surgery, University of Adelaide and the Basil Hetzel Institute for Translational Health Research, Central Adelaide Local Health Network, Woodville South, SA, Australia., Gummow J; Gene Silencing and Expression Core Facility, Adelaide Health and Medical Sciences, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia., Ferguson C; Infectious Diseases Department, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, SA, Australia., O'Connor S; Intensive Care Unit, Royal Adelaide Hospital, Central Adelaide Local Health Network and Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia., McCartney EM; Infectious Diseases Department, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, SA, Australia., Lynn DJ; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia; Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia., Maddern G; Discipline of Surgery, The University of Adelaide, Adelaide, SA 5000, Australia., Gowans EJ; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia., Reddi BAJ; Intensive Care Unit, Royal Adelaide Hospital, Central Adelaide Local Health Network and Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia., Shaw D; Infectious Diseases Department, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, SA, Australia., Kok-Lim C; Gene Silencing and Expression Core Facility, Adelaide Health and Medical Sciences, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia; Microbiology and Infectious Diseases Department, SA Pathology, Adelaide, SA, Australia; Research Centre for Infectious Diseases, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia., Beard MR; Research Centre for Infectious Diseases, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA., Turville SG; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia., Bull RA; School of Medical Sciences, Faculty of Medicine, UNSW, Australia, Sydney, NSW, Australia., Barry SC; Molecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia; Women's and Children's Health Network, North Adelaide, SA, Australia. Electronic address: simon.barry@adelaide.edu.au., Grubor-Bauk B; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia. Electronic address: branka.grubor@adelaide.edu.au.
Source: Cell reports. Medicine [Cell Rep Med] 2022 Jun 21; Vol. 3 (6), pp. 100651. Date of Electronic Publication: 2022 May 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents.
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  Data: <searchLink fieldCode="AU" term="%22Garcia-Valtanen+P%22">Garcia-Valtanen P</searchLink>; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Hope+CM%22">Hope CM</searchLink>; Molecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia; Women's and Children's Health Network, North Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Masavuli+MG%22">Masavuli MG</searchLink>; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Yeow+AEL%22">Yeow AEL</searchLink>; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Balachandran+H%22">Balachandran H</searchLink>; School of Medical Sciences, Faculty of Medicine, UNSW, Australia, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Mekonnen+ZA%22">Mekonnen ZA</searchLink>; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Al-Delfi+Z%22">Al-Delfi Z</searchLink>; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Abayasingam+A%22">Abayasingam A</searchLink>; School of Medical Sciences, Faculty of Medicine, UNSW, Australia, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Agapiou+D%22">Agapiou D</searchLink>; School of Medical Sciences, Faculty of Medicine, UNSW, Australia, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Stella+AO%22">Stella AO</searchLink>; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Aggarwal+A%22">Aggarwal A</searchLink>; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Bouras+G%22">Bouras G</searchLink>; Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia; The Department of Surgery - Otolaryngology, Head and Neck Surgery, University of Adelaide and the Basil Hetzel Institute for Translational Health Research, Central Adelaide Local Health Network, Woodville South, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Gummow+J%22">Gummow J</searchLink>; Gene Silencing and Expression Core Facility, Adelaide Health and Medical Sciences, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Ferguson+C%22">Ferguson C</searchLink>; Infectious Diseases Department, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22O'Connor+S%22">O'Connor S</searchLink>; Intensive Care Unit, Royal Adelaide Hospital, Central Adelaide Local Health Network and Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22McCartney+EM%22">McCartney EM</searchLink>; Infectious Diseases Department, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Lynn+DJ%22">Lynn DJ</searchLink>; Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA 5001, Australia; Flinders Health and Medical Research Institute, Flinders University, Bedford Park, SA 5042, Australia.<br /><searchLink fieldCode="AU" term="%22Maddern+G%22">Maddern G</searchLink>; Discipline of Surgery, The University of Adelaide, Adelaide, SA 5000, Australia.<br /><searchLink fieldCode="AU" term="%22Gowans+EJ%22">Gowans EJ</searchLink>; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Reddi+BAJ%22">Reddi BAJ</searchLink>; Intensive Care Unit, Royal Adelaide Hospital, Central Adelaide Local Health Network and Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Shaw+D%22">Shaw D</searchLink>; Infectious Diseases Department, Royal Adelaide Hospital, Central Adelaide Local Health Network, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Kok-Lim+C%22">Kok-Lim C</searchLink>; Gene Silencing and Expression Core Facility, Adelaide Health and Medical Sciences, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia; Microbiology and Infectious Diseases Department, SA Pathology, Adelaide, SA, Australia; Research Centre for Infectious Diseases, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Beard+MR%22">Beard MR</searchLink>; Research Centre for Infectious Diseases, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Weiskopf+D%22">Weiskopf D</searchLink>; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sette+A%22">Sette A</searchLink>; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Turville+SG%22">Turville SG</searchLink>; The Kirby Institute, The University of New South Wales, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Bull+RA%22">Bull RA</searchLink>; School of Medical Sciences, Faculty of Medicine, UNSW, Australia, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Barry+SC%22">Barry SC</searchLink>; Molecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia; Women's and Children's Health Network, North Adelaide, SA, Australia. Electronic address: simon.barry@adelaide.edu.au.<br /><searchLink fieldCode="AU" term="%22Grubor-Bauk+B%22">Grubor-Bauk B</searchLink>; Viral Immunology Group, Adelaide Medical School, University of Adelaide and Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia. Electronic address: branka.grubor@adelaide.edu.au.
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