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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.

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Title: Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
Authors: Brown KM; Alnylam Pharmaceuticals, Cambridge, MA, USA., Nair JK; Alnylam Pharmaceuticals, Cambridge, MA, USA., Janas MM; Alnylam Pharmaceuticals, Cambridge, MA, USA., Anglero-Rodriguez YI; Alnylam Pharmaceuticals, Cambridge, MA, USA., Dang LTH; Alnylam Pharmaceuticals, Cambridge, MA, USA., Peng H; Alnylam Pharmaceuticals, Cambridge, MA, USA., Theile CS; Alnylam Pharmaceuticals, Cambridge, MA, USA., Castellanos-Rizaldos E; Alnylam Pharmaceuticals, Cambridge, MA, USA., Brown C; Alnylam Pharmaceuticals, Cambridge, MA, USA., Foster D; Alnylam Pharmaceuticals, Cambridge, MA, USA., Kurz J; Alnylam Pharmaceuticals, Cambridge, MA, USA., Allen J; Alnylam Pharmaceuticals, Cambridge, MA, USA., Maganti R; Alnylam Pharmaceuticals, Cambridge, MA, USA., Li J; Alnylam Pharmaceuticals, Cambridge, MA, USA., Matsuda S; Alnylam Pharmaceuticals, Cambridge, MA, USA., Stricos M; Alnylam Pharmaceuticals, Cambridge, MA, USA., Chickering T; Alnylam Pharmaceuticals, Cambridge, MA, USA., Jung M; Alnylam Pharmaceuticals, Cambridge, MA, USA., Wassarman K; Alnylam Pharmaceuticals, Cambridge, MA, USA., Rollins J; Alnylam Pharmaceuticals, Cambridge, MA, USA., Woods L; Alnylam Pharmaceuticals, Cambridge, MA, USA., Kelin A; Alnylam Pharmaceuticals, Cambridge, MA, USA., Guenther DC; Alnylam Pharmaceuticals, Cambridge, MA, USA., Mobley MW; Alnylam Pharmaceuticals, Cambridge, MA, USA., Petrulis J; Alnylam Pharmaceuticals, Cambridge, MA, USA., McDougall R; Alnylam Pharmaceuticals, Cambridge, MA, USA., Racie T; Alnylam Pharmaceuticals, Cambridge, MA, USA., Bombardier J; Alnylam Pharmaceuticals, Cambridge, MA, USA., Cha D; Alnylam Pharmaceuticals, Cambridge, MA, USA., Agarwal S; Alnylam Pharmaceuticals, Cambridge, MA, USA., Johnson L; Alnylam Pharmaceuticals, Cambridge, MA, USA., Jiang Y; Alnylam Pharmaceuticals, Cambridge, MA, USA., Lentini S; Alnylam Pharmaceuticals, Cambridge, MA, USA., Gilbert J; Alnylam Pharmaceuticals, Cambridge, MA, USA., Nguyen T; Alnylam Pharmaceuticals, Cambridge, MA, USA., Chigas S; Alnylam Pharmaceuticals, Cambridge, MA, USA., LeBlanc S; Alnylam Pharmaceuticals, Cambridge, MA, USA., Poreci U; Alnylam Pharmaceuticals, Cambridge, MA, USA., Kasper A; Alnylam Pharmaceuticals, Cambridge, MA, USA., Rogers AB; Alnylam Pharmaceuticals, Cambridge, MA, USA., Chong S; Alnylam Pharmaceuticals, Cambridge, MA, USA., Davis W; Alnylam Pharmaceuticals, Cambridge, MA, USA., Sutherland JE; Alnylam Pharmaceuticals, Cambridge, MA, USA., Castoreno A; Alnylam Pharmaceuticals, Cambridge, MA, USA., Milstein S; Alnylam Pharmaceuticals, Cambridge, MA, USA., Schlegel MK; Alnylam Pharmaceuticals, Cambridge, MA, USA., Zlatev I; Alnylam Pharmaceuticals, Cambridge, MA, USA., Charisse K; Alnylam Pharmaceuticals, Cambridge, MA, USA., Keating M; Alnylam Pharmaceuticals, Cambridge, MA, USA., Manoharan M; Alnylam Pharmaceuticals, Cambridge, MA, USA., Fitzgerald K; Alnylam Pharmaceuticals, Cambridge, MA, USA., Wu JT; Alnylam Pharmaceuticals, Cambridge, MA, USA., Maier MA; Alnylam Pharmaceuticals, Cambridge, MA, USA. mmaier@alnylam.com., Jadhav V; Alnylam Pharmaceuticals, Cambridge, MA, USA. vjadhav@alnylam.com.
Source: Nature biotechnology [Nat Biotechnol] 2022 Oct; Vol. 40 (10), pp. 1500-1508. Date of Electronic Publication: 2022 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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