A target expression threshold dictates invader defense and prevents autoimmunity by CRISPR-Cas13.

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Bibliographic Details
Title: A target expression threshold dictates invader defense and prevents autoimmunity by CRISPR-Cas13.
Authors: Vialetto E; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Würzburg, Germany., Yu Y; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Würzburg, Germany., Collins SP; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA., Wandera KG; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Würzburg, Germany., Barquist L; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Würzburg, Germany; Medical Faculty, University of Würzburg, 97080 Würzburg, Germany., Beisel CL; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), 97080 Würzburg, Germany; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA; Medical Faculty, University of Würzburg, 97080 Würzburg, Germany. Electronic address: chase.beisel@helmholtz-hiri.de.
Source: Cell host & microbe [Cell Host Microbe] 2022 Aug 10; Vol. 30 (8), pp. 1151-1162.e6. Date of Electronic Publication: 2022 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1934-6069
DOI:10.1016/j.chom.2022.05.013