Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial.
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| Title: | Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial. |
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| Authors: | Li G; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Cappuccini F; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK; Jenner Institute, University of Oxford, Old Road Campus, Oxford, UK., Marchevsky NG; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Aley PK; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Aley R; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Anslow R; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Bibi S; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Cathie K; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Clutterbuck E; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Faust SN; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK., Feng S; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Heath PT; Vaccine Institute, St George's, University of London and St George's University Hospitals NHS Trust, London, UK., Kerridge S; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Lelliott A; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Mujadidi Y; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Ng KF; Bristol Royal Hospital for Children, University of Bristol, Bristol, UK., Rhead S; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Roberts H; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Robinson H; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Roderick MR; Bristol Royal Hospital for Children, University of Bristol, Bristol, UK., Singh N; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Smith D; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Snape MD; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Song R; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Tang K; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Yao A; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK., Liu X; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK. Electronic address: xinxue.liu@paediatrics.ox.ac.uk., Lambe T; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK., Pollard AJ; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK. |
| Corporate Authors: | COV006 study team |
| Source: | Lancet (London, England) [Lancet] 2022 Jun 11; Vol. 399 (10342), pp. 2212-2225. |
| Publication Type: | Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 35691324 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Li+G%22">Li G</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cappuccini+F%22">Cappuccini F</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK; Jenner Institute, University of Oxford, Old Road Campus, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Marchevsky+NG%22">Marchevsky NG</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Aley+PK%22">Aley PK</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Aley+R%22">Aley R</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Anslow+R%22">Anslow R</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bibi+S%22">Bibi S</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cathie+K%22">Cathie K</searchLink>; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Clutterbuck+E%22">Clutterbuck E</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Faust+SN%22">Faust SN</searchLink>; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Feng+S%22">Feng S</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Heath+PT%22">Heath PT</searchLink>; Vaccine Institute, St George's, University of London and St George's University Hospitals NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Kerridge+S%22">Kerridge S</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lelliott+A%22">Lelliott A</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Mujadidi+Y%22">Mujadidi Y</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ng+KF%22">Ng KF</searchLink>; Bristol Royal Hospital for Children, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Rhead+S%22">Rhead S</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+H%22">Roberts H</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Robinson+H%22">Robinson H</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Roderick+MR%22">Roderick MR</searchLink>; Bristol Royal Hospital for Children, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Singh+N%22">Singh N</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Smith+D%22">Smith D</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Snape+MD%22">Snape MD</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Song+R%22">Song R</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Tang+K%22">Tang K</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Yao+A%22">Yao A</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK. Electronic address: xinxue.liu@paediatrics.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Lambe+T%22">Lambe T</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK; Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Pollard+AJ%22">Pollard AJ</searchLink>; Oxford Vaccine Group, Department of Paediatrics Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22COV006+study+team%22">COV006 study team</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2022 Jun 11; Vol. 399 (10342), pp. 2212-2225. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985213R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-547X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201406736%22">01406736 </searchLink><i>NLM ISO Abbreviation: </i>Lancet <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=35691324 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S0140-6736(22)00770-X Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 2212 Titles: – TitleFull: Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: a preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li G – PersonEntity: Name: NameFull: Cappuccini F – PersonEntity: Name: NameFull: Marchevsky NG – PersonEntity: Name: NameFull: Aley PK – PersonEntity: Name: NameFull: Aley R – PersonEntity: Name: NameFull: Anslow R – PersonEntity: Name: NameFull: Bibi S – PersonEntity: Name: NameFull: Cathie K – PersonEntity: Name: NameFull: Clutterbuck E – PersonEntity: Name: NameFull: Faust SN – PersonEntity: Name: NameFull: Feng S – PersonEntity: Name: NameFull: Heath PT – PersonEntity: Name: NameFull: Kerridge S – PersonEntity: Name: NameFull: Lelliott A – PersonEntity: Name: NameFull: Mujadidi Y – PersonEntity: Name: NameFull: Ng KF – PersonEntity: Name: NameFull: Rhead S – PersonEntity: Name: NameFull: Roberts H – PersonEntity: Name: NameFull: Robinson H – PersonEntity: Name: NameFull: Roderick MR – PersonEntity: Name: NameFull: Singh N – PersonEntity: Name: NameFull: Smith D – PersonEntity: Name: NameFull: Snape MD – PersonEntity: Name: NameFull: Song R – PersonEntity: Name: NameFull: Tang K – PersonEntity: Name: NameFull: Yao A – PersonEntity: Name: NameFull: Liu X – PersonEntity: Name: NameFull: Lambe T – PersonEntity: Name: NameFull: Pollard AJ IsPartOfRelationships: – BibEntity: Dates: – D: 11 M: 06 Text: 2022 Jun 11 Type: published Y: 2022 Identifiers: – Type: issn-electronic Value: 1474-547X Numbering: – Type: volume Value: 399 – Type: issue Value: 10342 Titles: – TitleFull: Lancet (London, England) Type: main |
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