(1 → 3)-β-D-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial.

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Title: (1 → 3)-β-D-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial.
Authors: Bloos F; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany. frank.bloos@med.uni-jena.de.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany. frank.bloos@med.uni-jena.de., Held J; Mikrobiologisches Institut-Klinische Mikrobiologie Immunologie und Hygiene, Universitätsklinikum Erlangen Und Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany., Kluge S; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Simon P; Department of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Centre, Leipzig, Germany.; Department of Anesthesiology and Surgical Intensive Care Medicine, University Hospital Augsburg, Augsburg, Germany., Kogelmann K; Department of Anesthesiology and Intensive Care Medicine, Hospital Emden, Emden, Germany., de Heer G; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Kuhn SO; Department of Anesthesiology and Intensive Care Medicine, University Hospital Greifswald, Greifswald, Germany., Jarczak D; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Motsch J; Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany., Hempel G; Department of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Centre, Leipzig, Germany., Weiler N; Department of Anesthesiology and Intensive Care Medicine, University Medical Center Kiel, Kiel, Germany., Weyland A; Research Center Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany., Drüner M; Department of Anesthesiology and Intensive Care Medicine, Hospital Emden, Emden, Germany., Gründling M; Department of Anesthesiology and Intensive Care Medicine, University Hospital Greifswald, Greifswald, Germany., Meybohm P; Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Würzburg, Germany., Richter D; Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany., Jaschinski U; Department of Anesthesiology and Surgical Intensive Care Medicine, University Hospital Augsburg, Augsburg, Germany., Moerer O; Department of Anesthesiology, University Medical Center, Georg-August-University, Göttingen, Germany., Günther U; University Clinic of Anaesthesiology, Intensive Care, Emergency Medicine and Pain Therapy, Klinikum Oldenburg, Oldenburg, Germany., Schädler D; Department of Anesthesiology and Intensive Care Medicine, University Medical Center Kiel, Kiel, Germany., Weiss R; Department of Anesthesiology, Surgical Intensive Care Medicine and Pain Therapy, University Hospital Münster, Munster, Germany., Putensen C; Division of Intensive Care Medicine, Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany., Castellanos I; Department of Anesthesiology, University Hospital, Erlangen, Germany., Kurzai O; Institute for Hygiene and Microbiology, Julius Maximilians University Würzburg, Würzburg, Germany.; National Reference Center for Invasive Fungal Infections NRZMyk, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knoell-Insitute, Jena, Germany., Schlattmann P; Institute of Medical Statistics, Computer Sciences and Data Science, Jena University Hospital, Jena, Germany., Cornely OA; Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Chair Translational Research, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany., Bauer M; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany., Thomas-Rüddel D; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.
Corporate Authors: SepNet Study Group
Source: Intensive care medicine [Intensive Care Med] 2022 Jul; Vol. 48 (7), pp. 865-875. Date of Electronic Publication: 2022 Jun 16.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7704851 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1238 (Electronic) Linking ISSN: 03424642 NLM ISO Abbreviation: Intensive Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: (1 → 3)-β-D-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Bloos+F%22">Bloos F</searchLink>; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany. frank.bloos@med.uni-jena.de.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany. frank.bloos@med.uni-jena.de.<br /><searchLink fieldCode="AU" term="%22Held+J%22">Held J</searchLink>; Mikrobiologisches Institut-Klinische Mikrobiologie Immunologie und Hygiene, Universitätsklinikum Erlangen Und Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Kluge+S%22">Kluge S</searchLink>; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Simon+P%22">Simon P</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Centre, Leipzig, Germany.; Department of Anesthesiology and Surgical Intensive Care Medicine, University Hospital Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kogelmann+K%22">Kogelmann K</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Hospital Emden, Emden, Germany.<br /><searchLink fieldCode="AU" term="%22de+Heer+G%22">de Heer G</searchLink>; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kuhn+SO%22">Kuhn SO</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Hospital Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Jarczak+D%22">Jarczak D</searchLink>; Department of Intensive Care Medicine, University Hospital Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Motsch+J%22">Motsch J</searchLink>; Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hempel+G%22">Hempel G</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Centre, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Weiler+N%22">Weiler N</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Medical Center Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Weyland+A%22">Weyland A</searchLink>; Research Center Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.<br /><searchLink fieldCode="AU" term="%22Drüner+M%22">Drüner M</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Hospital Emden, Emden, Germany.<br /><searchLink fieldCode="AU" term="%22Gründling+M%22">Gründling M</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Hospital Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Meybohm+P%22">Meybohm P</searchLink>; Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Richter+D%22">Richter D</searchLink>; Department of Anesthesiology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jaschinski+U%22">Jaschinski U</searchLink>; Department of Anesthesiology and Surgical Intensive Care Medicine, University Hospital Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Moerer+O%22">Moerer O</searchLink>; Department of Anesthesiology, University Medical Center, Georg-August-University, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Günther+U%22">Günther U</searchLink>; University Clinic of Anaesthesiology, Intensive Care, Emergency Medicine and Pain Therapy, Klinikum Oldenburg, Oldenburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schädler+D%22">Schädler D</searchLink>; Department of Anesthesiology and Intensive Care Medicine, University Medical Center Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Weiss+R%22">Weiss R</searchLink>; Department of Anesthesiology, Surgical Intensive Care Medicine and Pain Therapy, University Hospital Münster, Munster, Germany.<br /><searchLink fieldCode="AU" term="%22Putensen+C%22">Putensen C</searchLink>; Division of Intensive Care Medicine, Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Castellanos+I%22">Castellanos I</searchLink>; Department of Anesthesiology, University Hospital, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Kurzai+O%22">Kurzai O</searchLink>; Institute for Hygiene and Microbiology, Julius Maximilians University Würzburg, Würzburg, Germany.; National Reference Center for Invasive Fungal Infections NRZMyk, Leibniz Institute for Natural Product Research and Infection Biology-Hans-Knoell-Insitute, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Schlattmann+P%22">Schlattmann P</searchLink>; Institute of Medical Statistics, Computer Sciences and Data Science, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Cornely+OA%22">Cornely OA</searchLink>; Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Chair Translational Research, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Bauer+M%22">Bauer M</searchLink>; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Thomas-Rüddel+D%22">Thomas-Rüddel D</searchLink>; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany.
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