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Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia.

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Title: Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia.
Authors: Garcia-Bermudez J; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Badgley MA; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA., Prasad S; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA., Baudrier L; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA., Liu Y; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA., La K; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA., Soula M; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA., Williams RT; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA., Yamaguchi N; Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA., Hwang RF; Department of Breast Surgical Oncology, Division of Surgery, MD Anderson Cancer Center, University of Texas, Houston, TX, USA., Taylor LJ; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA., de Stanchina E; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Rostandy B; The Proteomics Resource Center, The Rockefeller University, New York, NY, USA., Alwaseem H; The Proteomics Resource Center, The Rockefeller University, New York, NY, USA., Molina H; The Proteomics Resource Center, The Rockefeller University, New York, NY, USA., Bar-Sagi D; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA. dafna.bar-sagi@nyulangone.org., Birsoy K; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA. kbirsoy@rockefeller.edu.
Source: Nature metabolism [Nat Metab] 2022 Jun; Vol. 4 (6), pp. 724-738. Date of Electronic Publication: 2022 Jun 20.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia.
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  Data: <searchLink fieldCode="AU" term="%22Garcia-Bermudez+J%22">Garcia-Bermudez J</searchLink>; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Badgley+MA%22">Badgley MA</searchLink>; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Prasad+S%22">Prasad S</searchLink>; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Baudrier+L%22">Baudrier L</searchLink>; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22La+K%22">La K</searchLink>; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Soula+M%22">Soula M</searchLink>; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Williams+RT%22">Williams RT</searchLink>; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yamaguchi+N%22">Yamaguchi N</searchLink>; Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hwang+RF%22">Hwang RF</searchLink>; Department of Breast Surgical Oncology, Division of Surgery, MD Anderson Cancer Center, University of Texas, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Taylor+LJ%22">Taylor LJ</searchLink>; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22de+Stanchina+E%22">de Stanchina E</searchLink>; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rostandy+B%22">Rostandy B</searchLink>; The Proteomics Resource Center, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Alwaseem+H%22">Alwaseem H</searchLink>; The Proteomics Resource Center, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Molina+H%22">Molina H</searchLink>; The Proteomics Resource Center, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bar-Sagi+D%22">Bar-Sagi D</searchLink>; Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA. dafna.bar-sagi@nyulangone.org.<br /><searchLink fieldCode="AU" term="%22Birsoy+K%22">Birsoy K</searchLink>; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA. kbirsoy@rockefeller.edu.
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  Data: <searchLink fieldCode="JN" term="%22101736592%22">Nature metabolism</searchLink> [Nat Metab] 2022 Jun; Vol. 4 (6), pp. 724-738. <i>Date of Electronic Publication: </i>2022 Jun 20.
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