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Variability of Primary Sjögren's Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA-DQ Locus.

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Title: Variability of Primary Sjögren's Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA-DQ Locus.
Authors: Trutschel D; Computational Systems Biomedicine Lab, Institut Pasteur, Université Paris Cité, Paris, France., Bost P; Computational Systems Biomedicine Lab, Institut Pasteur, Université Paris Cité, Paris, France, Department of Quantitative Biomedicine, University of Zurich, and ETH Zurich, Institute for Molecular Health Sciences, Zurich, Switzerland., Mariette X; Department of Rheumatology, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, INSERM UMR1184-Immunology of viral infections and autoimmune diseases, Le Kremlin Bicêtre, France., Bondet V; Department of Immunology, Translational Immunology Unit, Institut Pasteur, Universite Cité Paris, Paris, France., Llibre A; Department of Immunology, Translational Immunology Unit, Institut Pasteur, Universite Cité Paris, Paris, France., Posseme C; Department of Immunology, Translational Immunology Unit, Institut Pasteur, Universite Cité Paris, Paris, France., Charbit B; Cytometry and Biomarkers UTechS, CRT, Institut Pasteur, Université Cite Paris, Institut Pasteur, Paris, France., Thorball CW; School of Life Sciences, École Polytechnique Fédérale de Lausanne, and Precision Medicine Unit, Biomedical Data Science Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Jonsson R; Department of Rheumatology, Haukeland University Hospital, and Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway., Lessard CJ; Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma., Felten R; Department of Rheumatology, Strasbourg University Hospital, National Centre For Rare Systemic Autoimmune Diseases, and Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg University, Strasbourg, France., Ng WF; Translational and Clinical Research Institute, Newcastle University, NIHR Newcastle Biomedical Centre, and NIHR Newcastle Clinical Research Facility, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Chatenoud L; Université Paris Descartes, Sorbonne Paris Cité, INEM, CNRS UMR8253, Hôpital Necker-Enfants Malades, Paris, France., Dumortier H; Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg University, Strasbourg, France., Sibilia J; Department of Rheumatology, Strasbourg University Hospital, National Centre For Rare Systemic Autoimmune Diseases, CNRS UPR3572, Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg University, Strasbourg, France., Fellay J; School of Life Sciences, École Polytechnique Fédérale de Lausanne, and Precision Medicine Unit, Biomedical Data Science Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Brokstad KA; Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway., Appel S; Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway., Tarn JR; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Quintana-Murci L; Department of Genomes & Genetics, Human Evolutionary Genetics, Institut Pasteur, CNRS URA3012, Paris, France., Mingueneau M; Multiple Sclerosis and Neurorepair Research Unit, Biogen, Cambridge, Massachusetts., Meyer N; CHU de Strasbourg, Service de Santé Publique, GMRC, Strasbourg, France, and CNRS, iCUBE, UMR7357, Illkirch, France., Duffy D; Department of Immunology, Translational Immunology Unit, Institut Pasteur, Universite Cité Paris, Paris, France., Schwikowski B; Computational Systems Biomedicine Lab, Institut Pasteur, Université Paris Cité, Paris, France., Gottenberg JE; Department of Rheumatology, Strasbourg University Hospital, National Centre For Rare Systemic Autoimmune Diseases, and Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg University, Strasbourg, France.
Corporate Authors: Milieu Intérieur Consortium, ASSESS study investigators, and NECESSITY Consortium
Source: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2022 Dec; Vol. 74 (12), pp. 1991-2002. Date of Electronic Publication: 2022 Nov 02.
Publication Type: Multicenter Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Variability of Primary Sjögren's Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA-DQ Locus.
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  Data: <searchLink fieldCode="AU" term="%22Trutschel+D%22">Trutschel D</searchLink>; Computational Systems Biomedicine Lab, Institut Pasteur, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bost+P%22">Bost P</searchLink>; Computational Systems Biomedicine Lab, Institut Pasteur, Université Paris Cité, Paris, France, Department of Quantitative Biomedicine, University of Zurich, and ETH Zurich, Institute for Molecular Health Sciences, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mariette+X%22">Mariette X</searchLink>; Department of Rheumatology, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, INSERM UMR1184-Immunology of viral infections and autoimmune diseases, Le Kremlin Bicêtre, France.<br /><searchLink fieldCode="AU" term="%22Bondet+V%22">Bondet V</searchLink>; Department of Immunology, Translational Immunology Unit, Institut Pasteur, Universite Cité Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Llibre+A%22">Llibre A</searchLink>; Department of Immunology, Translational Immunology Unit, Institut Pasteur, Universite Cité Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Posseme+C%22">Posseme C</searchLink>; Department of Immunology, Translational Immunology Unit, Institut Pasteur, Universite Cité Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Charbit+B%22">Charbit B</searchLink>; Cytometry and Biomarkers UTechS, CRT, Institut Pasteur, Université Cite Paris, Institut Pasteur, Paris, France.<br /><searchLink fieldCode="AU" term="%22Thorball+CW%22">Thorball CW</searchLink>; School of Life Sciences, École Polytechnique Fédérale de Lausanne, and Precision Medicine Unit, Biomedical Data Science Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jonsson+R%22">Jonsson R</searchLink>; Department of Rheumatology, Haukeland University Hospital, and Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Lessard+CJ%22">Lessard CJ</searchLink>; Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.<br /><searchLink fieldCode="AU" term="%22Felten+R%22">Felten R</searchLink>; Department of Rheumatology, Strasbourg University Hospital, National Centre For Rare Systemic Autoimmune Diseases, and Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg University, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Ng+WF%22">Ng WF</searchLink>; Translational and Clinical Research Institute, Newcastle University, NIHR Newcastle Biomedical Centre, and NIHR Newcastle Clinical Research Facility, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Chatenoud+L%22">Chatenoud L</searchLink>; Université Paris Descartes, Sorbonne Paris Cité, INEM, CNRS UMR8253, Hôpital Necker-Enfants Malades, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dumortier+H%22">Dumortier H</searchLink>; Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg University, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Sibilia+J%22">Sibilia J</searchLink>; Department of Rheumatology, Strasbourg University Hospital, National Centre For Rare Systemic Autoimmune Diseases, CNRS UPR3572, Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg University, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Fellay+J%22">Fellay J</searchLink>; School of Life Sciences, École Polytechnique Fédérale de Lausanne, and Precision Medicine Unit, Biomedical Data Science Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Brokstad+KA%22">Brokstad KA</searchLink>; Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Appel+S%22">Appel S</searchLink>; Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Tarn+JR%22">Tarn JR</searchLink>; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Quintana-Murci+L%22">Quintana-Murci L</searchLink>; Department of Genomes & Genetics, Human Evolutionary Genetics, Institut Pasteur, CNRS URA3012, Paris, France.<br /><searchLink fieldCode="AU" term="%22Mingueneau+M%22">Mingueneau M</searchLink>; Multiple Sclerosis and Neurorepair Research Unit, Biogen, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Meyer+N%22">Meyer N</searchLink>; CHU de Strasbourg, Service de Santé Publique, GMRC, Strasbourg, France, and CNRS, iCUBE, UMR7357, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Duffy+D%22">Duffy D</searchLink>; Department of Immunology, Translational Immunology Unit, Institut Pasteur, Universite Cité Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Schwikowski+B%22">Schwikowski B</searchLink>; Computational Systems Biomedicine Lab, Institut Pasteur, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Gottenberg+JE%22">Gottenberg JE</searchLink>; Department of Rheumatology, Strasbourg University Hospital, National Centre For Rare Systemic Autoimmune Diseases, and Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg University, Strasbourg, France.
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  Data: <searchLink fieldCode="JN" term="%22101623795%22">Arthritis & rheumatology (Hoboken, N.J.)</searchLink> [Arthritis Rheumatol] 2022 Dec; Vol. 74 (12), pp. 1991-2002. <i>Date of Electronic Publication: </i>2022 Nov 02.
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