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Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited.

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Title: Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited.
Authors: Li Z; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Ji BW; Department of Systems Biology, Columbia University, New York, NY, USA.; Physician-Scientist Training Pathway, Department of Medicine, University of California, San Diego, San Diego, CA, USA., Dixit PD; Department of Systems Biology, Columbia University, New York, NY, USA.; Department of Physics, University of Florida, Gainesville, FL, USA.; University of Florida Genetics Institute, University of Florida, Gainesville, FL, USA.; Department of Chemical Engineering, University of Florida, Gainesville, FL, USA.; University of Florida Cancer Center, University of Florida, Gainesville, FL, USA., Tchourine K; Department of Systems Biology, Columbia University, New York, NY, USA., Lien EC; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Hosios AM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Abbott KL; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Rutter JC; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Health Sciences and Technology (HST) and Harvard/MIT MD-PhD Program, Harvard Medical School, Boston, MA, USA., Westermark AM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Gorodetsky EF; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Sullivan LB; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. mvh@mit.edu.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. mvh@mit.edu.; Dana-Farber Cancer Institute, Boston, MA, USA. mvh@mit.edu., Vitkup D; Department of Systems Biology, Columbia University, New York, NY, USA. dv2121@cumc.columbia.edu.; Department of Biomedical Informatics, Columbia University, New York, NY, USA. dv2121@cumc.columbia.edu.
Source: Nature metabolism [Nat Metab] 2022 Jun; Vol. 4 (6), pp. 711-723. Date of Electronic Publication: 2022 Jun 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited.
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  Data: <searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ji+BW%22">Ji BW</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.; Physician-Scientist Training Pathway, Department of Medicine, University of California, San Diego, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dixit+PD%22">Dixit PD</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.; Department of Physics, University of Florida, Gainesville, FL, USA.; University of Florida Genetics Institute, University of Florida, Gainesville, FL, USA.; Department of Chemical Engineering, University of Florida, Gainesville, FL, USA.; University of Florida Cancer Center, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Tchourine+K%22">Tchourine K</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lien+EC%22">Lien EC</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hosios+AM%22">Hosios AM</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Abbott+KL%22">Abbott KL</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rutter+JC%22">Rutter JC</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Health Sciences and Technology (HST) and Harvard/MIT MD-PhD Program, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Westermark+AM%22">Westermark AM</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gorodetsky+EF%22">Gorodetsky EF</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sullivan+LB%22">Sullivan LB</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Vander+Heiden+MG%22">Vander Heiden MG</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. mvh@mit.edu.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. mvh@mit.edu.; Dana-Farber Cancer Institute, Boston, MA, USA. mvh@mit.edu.<br /><searchLink fieldCode="AU" term="%22Vitkup+D%22">Vitkup D</searchLink>; Department of Systems Biology, Columbia University, New York, NY, USA. dv2121@cumc.columbia.edu.; Department of Biomedical Informatics, Columbia University, New York, NY, USA. dv2121@cumc.columbia.edu.
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