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Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition.

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Title: Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition.
Authors: Huynh MV; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Parsonage D; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Forshaw TE; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Chirasani VR; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Hobbs GA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Wu H; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Lee J; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA., Furdui CM; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA; Center for Redox Biology and Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Poole LB; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA; Center for Redox Biology and Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Electronic address: lbpoole@wakehealth.edu., Campbell SL; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address: campbesl@med.unc.edu.
Source: The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102186. Date of Electronic Publication: 2022 Jun 24.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Huynh+MV%22">Huynh MV</searchLink>; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Parsonage+D%22">Parsonage D</searchLink>; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Forshaw+TE%22">Forshaw TE</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Chirasani+VR%22">Chirasani VR</searchLink>; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Hobbs+GA%22">Hobbs GA</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Furdui+CM%22">Furdui CM</searchLink>; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA; Center for Redox Biology and Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Poole+LB%22">Poole LB</searchLink>; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA; Center for Redox Biology and Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Electronic address: lbpoole@wakehealth.edu.<br /><searchLink fieldCode="AU" term="%22Campbell+SL%22">Campbell SL</searchLink>; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address: campbesl@med.unc.edu.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102186. <i>Date of Electronic Publication: </i>2022 Jun 24.
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        Value: 10.1016/j.jbc.2022.102186
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              Text: 2022 Aug
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