Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition.
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| Title: | Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition. |
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| Authors: | Huynh MV; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Parsonage D; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Forshaw TE; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Chirasani VR; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Hobbs GA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Wu H; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Lee J; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA., Furdui CM; Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA; Center for Redox Biology and Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Poole LB; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA; Center for Redox Biology and Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. Electronic address: lbpoole@wakehealth.edu., Campbell SL; Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address: campbesl@med.unc.edu. |
| Source: | The Journal of biological chemistry [J Biol Chem] 2022 Aug; Vol. 298 (8), pp. 102186. Date of Electronic Publication: 2022 Jun 24. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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