Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction.

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Title: Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction.
Authors: Mahmud Z; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada., Tikunova S; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States., Belevych N; Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, United States., Wagg CS; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Zhabyeyev P; Department of Medicine, University of Alberta, Edmonton, AB, Canada., Liu PB; Department of Medicine, University of Alberta, Edmonton, AB, Canada., Rasicci DV; Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, University Park, PA, United States., Yengo CM; Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, University Park, PA, United States., Oudit GY; Department of Medicine, University of Alberta, Edmonton, AB, Canada., Lopaschuk GD; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Reiser PJ; Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, OH, United States., Davis JP; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, United States., Hwang PM; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.; Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Source: Frontiers in physiology [Front Physiol] 2022 Jun 08; Vol. 13, pp. 892979. Date of Electronic Publication: 2022 Jun 08 (Print Publication: 2022).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-042X
DOI:10.3389/fphys.2022.892979