Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.
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| Title: | Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine. |
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| Authors: | Cangelosi AL; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Puszynska AM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Roberts JM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Armani A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Nguyen TP; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Spinelli JB; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kunchok T; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Wang B; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Chan SH; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Lewis CA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Comb WC; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bell GW; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Helman A; Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel., Sabatini DM; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. |
| Source: | Science (New York, N.Y.) [Science] 2022 Jul; Vol. 377 (6601), pp. 47-56. Date of Electronic Publication: 2022 Jun 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.abi9547 |