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Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.

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Title: Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.
Authors: Cangelosi AL; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Puszynska AM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Roberts JM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Armani A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy., Nguyen TP; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Spinelli JB; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kunchok T; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Wang B; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Chan SH; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Lewis CA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Comb WC; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bell GW; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Helman A; Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel., Sabatini DM; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Source: Science (New York, N.Y.) [Science] 2022 Jul; Vol. 377 (6601), pp. 47-56. Date of Electronic Publication: 2022 Jun 30.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine.
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  Data: <searchLink fieldCode="AU" term="%22Cangelosi+AL%22">Cangelosi AL</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Puszynska+AM%22">Puszynska AM</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+JM%22">Roberts JM</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Armani+A%22">Armani A</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Veneto Institute of Molecular Medicine, 35129 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Nguyen+TP%22">Nguyen TP</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Spinelli+JB%22">Spinelli JB</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Kunchok+T%22">Kunchok T</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Chan+SH%22">Chan SH</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+CA%22">Lewis CA</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Comb+WC%22">Comb WC</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Bell+GW%22">Bell GW</searchLink>; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Helman+A%22">Helman A</searchLink>; Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel.<br /><searchLink fieldCode="AU" term="%22Sabatini+DM%22">Sabatini DM</searchLink>; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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