Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.

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Title: Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
Authors: Axelsson Raja A; Department of Genetics, Harvard Medical School, Boston, MA 02115.; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, 2100 Copenhagen, Denmark., Wakimoto H; Department of Genetics, Harvard Medical School, Boston, MA 02115., DeLaughter DM; Department of Genetics, Harvard Medical School, Boston, MA 02115., Reichart D; Department of Genetics, Harvard Medical School, Boston, MA 02115., Gorham J; Department of Genetics, Harvard Medical School, Boston, MA 02115., Conner DA; Department of Genetics, Harvard Medical School, Boston, MA 02115., Lun M; Department of Genetics, Harvard Medical School, Boston, MA 02115., Probst CK; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Sakai N; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Nephrology, Kanazawa University, Kanazawa, 920-1192 Japan., Knipe RS; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Montesi SB; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Shea B; Division of Pulmonary, Critical Care and Sleep Medicine, Albert Medical School of Brown University, Providence, RI 02903., Adam LP; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08540., Leinwand LA; Biofrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80302., Wan W; Biofrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80302., Choi ES; Biofrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80302., Lindberg EL; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany., Patone G; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany., Noseda M; National Heart and Lung Institute, British Heart Foundation Centre of Regenerative Medicine, British Heart Foundation Centre of Research Excellence, Imperial College London, London SW7 2AZ, United Kingdom., Hübner N; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Charité-Universitätsmedizin, Berlin Institute of Health, 10117 Berlin, Germany.; German Centre for Cardiovascular Research, Partner Site Berlin, 13347 Berlin, Germany., Seidman CE; Department of Genetics, Harvard Medical School, Boston, MA 02115.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115.; HHMI, Chevy Chase, MD 20815., Tager AM; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Seidman JG; Department of Genetics, Harvard Medical School, Boston, MA 02115., Ho CY; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jul 12; Vol. 119 (28), pp. e2204174119. Date of Electronic Publication: 2022 Jul 05.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.2204174119