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Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.

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Title: Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
Authors: Axelsson Raja A; Department of Genetics, Harvard Medical School, Boston, MA 02115.; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, 2100 Copenhagen, Denmark., Wakimoto H; Department of Genetics, Harvard Medical School, Boston, MA 02115., DeLaughter DM; Department of Genetics, Harvard Medical School, Boston, MA 02115., Reichart D; Department of Genetics, Harvard Medical School, Boston, MA 02115., Gorham J; Department of Genetics, Harvard Medical School, Boston, MA 02115., Conner DA; Department of Genetics, Harvard Medical School, Boston, MA 02115., Lun M; Department of Genetics, Harvard Medical School, Boston, MA 02115., Probst CK; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Sakai N; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Nephrology, Kanazawa University, Kanazawa, 920-1192 Japan., Knipe RS; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Montesi SB; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Shea B; Division of Pulmonary, Critical Care and Sleep Medicine, Albert Medical School of Brown University, Providence, RI 02903., Adam LP; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08540., Leinwand LA; Biofrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80302., Wan W; Biofrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80302., Choi ES; Biofrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80302., Lindberg EL; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany., Patone G; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany., Noseda M; National Heart and Lung Institute, British Heart Foundation Centre of Regenerative Medicine, British Heart Foundation Centre of Research Excellence, Imperial College London, London SW7 2AZ, United Kingdom., Hübner N; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Charité-Universitätsmedizin, Berlin Institute of Health, 10117 Berlin, Germany.; German Centre for Cardiovascular Research, Partner Site Berlin, 13347 Berlin, Germany., Seidman CE; Department of Genetics, Harvard Medical School, Boston, MA 02115.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115.; HHMI, Chevy Chase, MD 20815., Tager AM; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114., Seidman JG; Department of Genetics, Harvard Medical School, Boston, MA 02115., Ho CY; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jul 12; Vol. 119 (28), pp. e2204174119. Date of Electronic Publication: 2022 Jul 05.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
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  Data: <searchLink fieldCode="AU" term="%22Axelsson+Raja+A%22">Axelsson Raja A</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA 02115.; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, 2100 Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Wakimoto+H%22">Wakimoto H</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22DeLaughter+DM%22">DeLaughter DM</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Reichart+D%22">Reichart D</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Gorham+J%22">Gorham J</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Conner+DA%22">Conner DA</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Lun+M%22">Lun M</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Probst+CK%22">Probst CK</searchLink>; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.<br /><searchLink fieldCode="AU" term="%22Sakai+N%22">Sakai N</searchLink>; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Nephrology, Kanazawa University, Kanazawa, 920-1192 Japan.<br /><searchLink fieldCode="AU" term="%22Knipe+RS%22">Knipe RS</searchLink>; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.<br /><searchLink fieldCode="AU" term="%22Montesi+SB%22">Montesi SB</searchLink>; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.<br /><searchLink fieldCode="AU" term="%22Shea+B%22">Shea B</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Albert Medical School of Brown University, Providence, RI 02903.<br /><searchLink fieldCode="AU" term="%22Adam+LP%22">Adam LP</searchLink>; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08540.<br /><searchLink fieldCode="AU" term="%22Leinwand+LA%22">Leinwand LA</searchLink>; Biofrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80302.<br /><searchLink fieldCode="AU" term="%22Wan+W%22">Wan W</searchLink>; Biofrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80302.<br /><searchLink fieldCode="AU" term="%22Choi+ES%22">Choi ES</searchLink>; Biofrontiers Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80302.<br /><searchLink fieldCode="AU" term="%22Lindberg+EL%22">Lindberg EL</searchLink>; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Patone+G%22">Patone G</searchLink>; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Noseda+M%22">Noseda M</searchLink>; National Heart and Lung Institute, British Heart Foundation Centre of Regenerative Medicine, British Heart Foundation Centre of Research Excellence, Imperial College London, London SW7 2AZ, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hübner+N%22">Hübner N</searchLink>; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.; Charité-Universitätsmedizin, Berlin Institute of Health, 10117 Berlin, Germany.; German Centre for Cardiovascular Research, Partner Site Berlin, 13347 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Seidman+CE%22">Seidman CE</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA 02115.; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115.; HHMI, Chevy Chase, MD 20815.<br /><searchLink fieldCode="AU" term="%22Tager+AM%22">Tager AM</searchLink>; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.; Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.<br /><searchLink fieldCode="AU" term="%22Seidman+JG%22">Seidman JG</searchLink>; Department of Genetics, Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Ho+CY%22">Ho CY</searchLink>; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2022 Jul 12; Vol. 119 (28), pp. e2204174119. <i>Date of Electronic Publication: </i>2022 Jul 05.
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