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The Common H202D Variant in GDF-15 Does Not Affect Its Bioactivity but Can Significantly Interfere with Measurement of Its Circulating Levels.

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Title: The Common H202D Variant in GDF-15 Does Not Affect Its Bioactivity but Can Significantly Interfere with Measurement of Its Circulating Levels.
Authors: Karusheva Y; MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Clinical Biochemistry, NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Ratcliff M; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK.; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK., Mörseburg A; MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Clinical Biochemistry, NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Barker P; Department of Clinical Biochemistry, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Core Biochemical Assay Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK., Melvin A; MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Clinical Biochemistry, NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Sattar N; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK., Burling K; Department of Clinical Biochemistry, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK., Backmark A; Discovery Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Roth R; Discovery Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Jermutus L; Projects, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Guiu-Jurado E; Department for Clinical Obesity Research, Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Blüher M; Department for Clinical Obesity Research, Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany., Welsh P; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK., Hyvönen M; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., O'Rahilly S; MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Clinical Biochemistry, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Source: The journal of applied laboratory medicine [J Appl Lab Med] 2022 Oct 29; Vol. 7 (6), pp. 1388-1400.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101693884 Publication Model: Print Cited Medium: Print ISSN: 2576-9456 (Print) Linking ISSN: 24757241 NLM ISO Abbreviation: J Appl Lab Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The Common H202D Variant in GDF-15 Does Not Affect Its Bioactivity but Can Significantly Interfere with Measurement of Its Circulating Levels.
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  Data: <searchLink fieldCode="AU" term="%22Karusheva+Y%22">Karusheva Y</searchLink>; MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Clinical Biochemistry, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ratcliff+M%22">Ratcliff M</searchLink>; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK.; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.<br /><searchLink fieldCode="AU" term="%22Mörseburg+A%22">Mörseburg A</searchLink>; MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Clinical Biochemistry, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Barker+P%22">Barker P</searchLink>; Department of Clinical Biochemistry, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Core Biochemical Assay Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Melvin+A%22">Melvin A</searchLink>; MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Clinical Biochemistry, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sattar+N%22">Sattar N</searchLink>; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.<br /><searchLink fieldCode="AU" term="%22Burling+K%22">Burling K</searchLink>; Department of Clinical Biochemistry, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK.<br /><searchLink fieldCode="AU" term="%22Backmark+A%22">Backmark A</searchLink>; Discovery Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Roth+R%22">Roth R</searchLink>; Discovery Biology, Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Jermutus+L%22">Jermutus L</searchLink>; Projects, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Guiu-Jurado+E%22">Guiu-Jurado E</searchLink>; Department for Clinical Obesity Research, Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Blüher+M%22">Blüher M</searchLink>; Department for Clinical Obesity Research, Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Welsh+P%22">Welsh P</searchLink>; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.<br /><searchLink fieldCode="AU" term="%22Hyvönen+M%22">Hyvönen M</searchLink>; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22O'Rahilly+S%22">O'Rahilly S</searchLink>; MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Clinical Biochemistry, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
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