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Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.

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Title: Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.
Authors: Robinson PS; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK., Thomas LE; Institute of Life Science, Swansea University, Swansea, SA28PP, UK., Abascal F; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Jung H; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Harvey LMR; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., West HD; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Olafsson S; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Lee BCH; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong., Coorens THH; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Lee-Six H; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Butlin L; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Lander N; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Truscott R; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Sanders MA; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Haematology, Erasmus University Medical Centre, 3015 CN, Rotterdam, The Netherlands., Lensing SV; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Buczacki SJA; Nuffield Department of Surgical Sciences, Medical Sciences Division, University of Oxford, Oxford, UK., Ten Hoopen R; Department of Oncology, University of Cambridge, Cambridge, UK., Coleman N; Department of Pathology, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Brunton-Sim R; Norfolk and Norwich University Hospital, Norwich, UK., Rushbrook S; Norfolk and Norwich University Hospital, Norwich, UK.; Norwich Medical School, University of East Anglia, Norwich, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK.; Cambridge NIHR Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Lalloo F; Manchester Centre for Genomic Medicine, Saint Mary's Hospital, Oxford Road, Manchester, UK., Campbell PJ; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Martincorena I; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Sampson JR; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Stratton MR; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK. mrs@sanger.ac.uk.
Source: Nature communications [Nat Commun] 2022 Jul 08; Vol. 13 (1), pp. 3949. Date of Electronic Publication: 2022 Jul 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.
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  Data: <searchLink fieldCode="AU" term="%22Robinson+PS%22">Robinson PS</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Thomas+LE%22">Thomas LE</searchLink>; Institute of Life Science, Swansea University, Swansea, SA28PP, UK.<br /><searchLink fieldCode="AU" term="%22Abascal+F%22">Abascal F</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Jung+H%22">Jung H</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Harvey+LMR%22">Harvey LMR</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22West+HD%22">West HD</searchLink>; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Olafsson+S%22">Olafsson S</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Lee+BCH%22">Lee BCH</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Coorens+THH%22">Coorens THH</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Lee-Six+H%22">Lee-Six H</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Butlin+L%22">Butlin L</searchLink>; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Lander+N%22">Lander N</searchLink>; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Truscott+R%22">Truscott R</searchLink>; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Sanders+MA%22">Sanders MA</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Haematology, Erasmus University Medical Centre, 3015 CN, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lensing+SV%22">Lensing SV</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Buczacki+SJA%22">Buczacki SJA</searchLink>; Nuffield Department of Surgical Sciences, Medical Sciences Division, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Ten+Hoopen+R%22">Ten Hoopen R</searchLink>; Department of Oncology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Coleman+N%22">Coleman N</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Brunton-Sim+R%22">Brunton-Sim R</searchLink>; Norfolk and Norwich University Hospital, Norwich, UK.<br /><searchLink fieldCode="AU" term="%22Rushbrook+S%22">Rushbrook S</searchLink>; Norfolk and Norwich University Hospital, Norwich, UK.; Norwich Medical School, University of East Anglia, Norwich, UK.<br /><searchLink fieldCode="AU" term="%22Saeb-Parsy+K%22">Saeb-Parsy K</searchLink>; Department of Surgery, University of Cambridge, Cambridge, UK.; Cambridge NIHR Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lalloo+F%22">Lalloo F</searchLink>; Manchester Centre for Genomic Medicine, Saint Mary's Hospital, Oxford Road, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+PJ%22">Campbell PJ</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Martincorena+I%22">Martincorena I</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Sampson+JR%22">Sampson JR</searchLink>; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Stratton+MR%22">Stratton MR</searchLink>; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK. mrs@sanger.ac.uk.
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