Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na+ Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases.

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Title: Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na+ Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases.
Authors: Coquerel Q; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France., Legendre C; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France., Frangieh J; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France., Waard S; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France., Montnach J; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France., Cmarko L; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France.; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 166 10 Prague, Czech Republic., Khoury J; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.; Laboratory of Applied Biotechnology, AZM Centre for Research in Biotechnology and Its Application, Doctoral School for Sciences and Technology, Tripoli 1352, Lebanon., Hassane CS; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.; Univ Angers, SONAS, SFR QUASAV, 49100 Angers, France., Bréard D; Univ Angers, SONAS, SFR QUASAV, 49100 Angers, France., Siegler B; Univ Angers, SONAS, SFR QUASAV, 49100 Angers, France., Fajloun Z; Laboratory of Applied Biotechnology, AZM Centre for Research in Biotechnology and Its Application, Doctoral School for Sciences and Technology, Tripoli 1352, Lebanon., De Pomyers H; Latoxan Laboratory, 26800 Portes lès Valence, France., Mabrouk K; CNRS, ICR, Aix Marseille Univ, 13397 Marseille, France., Weiss N; Department of Pathophysiology, First Faculty of Medicine, Charles University, 160 00 Prague, Czech Republic., Henrion D; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France., Richomme P; Univ Angers, SONAS, SFR QUASAV, 49100 Angers, France., Mattei C; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France., Waard M; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France., Le Ray AM; Univ Angers, SONAS, SFR QUASAV, 49100 Angers, France., Legros C; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.
Source: Molecules (Basel, Switzerland) [Molecules] 2022 Jun 28; Vol. 27 (13). Date of Electronic Publication: 2022 Jun 28.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
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  Data: Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na<superscript>+</superscript> Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases.
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  Data: <searchLink fieldCode="AU" term="%22Coquerel+Q%22">Coquerel Q</searchLink>; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.<br /><searchLink fieldCode="AU" term="%22Legendre+C%22">Legendre C</searchLink>; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.<br /><searchLink fieldCode="AU" term="%22Frangieh+J%22">Frangieh J</searchLink>; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France.<br /><searchLink fieldCode="AU" term="%22Waard+S%22">Waard S</searchLink>; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France.<br /><searchLink fieldCode="AU" term="%22Montnach+J%22">Montnach J</searchLink>; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France.<br /><searchLink fieldCode="AU" term="%22Cmarko+L%22">Cmarko L</searchLink>; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France.; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 166 10 Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Khoury+J%22">Khoury J</searchLink>; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.; Laboratory of Applied Biotechnology, AZM Centre for Research in Biotechnology and Its Application, Doctoral School for Sciences and Technology, Tripoli 1352, Lebanon.<br /><searchLink fieldCode="AU" term="%22Hassane+CS%22">Hassane CS</searchLink>; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.; Univ Angers, SONAS, SFR QUASAV, 49100 Angers, France.<br /><searchLink fieldCode="AU" term="%22Bréard+D%22">Bréard D</searchLink>; Univ Angers, SONAS, SFR QUASAV, 49100 Angers, France.<br /><searchLink fieldCode="AU" term="%22Siegler+B%22">Siegler B</searchLink>; Univ Angers, SONAS, SFR QUASAV, 49100 Angers, France.<br /><searchLink fieldCode="AU" term="%22Fajloun+Z%22">Fajloun Z</searchLink>; Laboratory of Applied Biotechnology, AZM Centre for Research in Biotechnology and Its Application, Doctoral School for Sciences and Technology, Tripoli 1352, Lebanon.<br /><searchLink fieldCode="AU" term="%22De+Pomyers+H%22">De Pomyers H</searchLink>; Latoxan Laboratory, 26800 Portes lès Valence, France.<br /><searchLink fieldCode="AU" term="%22Mabrouk+K%22">Mabrouk K</searchLink>; CNRS, ICR, Aix Marseille Univ, 13397 Marseille, France.<br /><searchLink fieldCode="AU" term="%22Weiss+N%22">Weiss N</searchLink>; Department of Pathophysiology, First Faculty of Medicine, Charles University, 160 00 Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Henrion+D%22">Henrion D</searchLink>; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.<br /><searchLink fieldCode="AU" term="%22Richomme+P%22">Richomme P</searchLink>; Univ Angers, SONAS, SFR QUASAV, 49100 Angers, France.<br /><searchLink fieldCode="AU" term="%22Mattei+C%22">Mattei C</searchLink>; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.<br /><searchLink fieldCode="AU" term="%22Waard+M%22">Waard M</searchLink>; Nantes Université, CHU Nantes, CNRS, INSERM, L'institut du Thorax, 44000 Nantes, France.<br /><searchLink fieldCode="AU" term="%22Le+Ray+AM%22">Le Ray AM</searchLink>; Univ Angers, SONAS, SFR QUASAV, 49100 Angers, France.<br /><searchLink fieldCode="AU" term="%22Legros+C%22">Legros C</searchLink>; Univ Angers, INSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, 49000 Angers, France.
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  Data: <searchLink fieldCode="JN" term="%22100964009%22">Molecules (Basel, Switzerland)</searchLink> [Molecules] 2022 Jun 28; Vol. 27 (13). <i>Date of Electronic Publication: </i>2022 Jun 28.
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